Results 131 to 140 of about 4,941,141 (298)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Известия высших учебных заведений. Поволжский регион: Физико-математические наукиBackground. In the literature, loaded differential equations are usually called equations containing functions of the solution on manifolds of smaller dimension than the dimension of the domain of definition of the sought function.
Zaryana V. Beshtokova +2 more
doaj +1 more source
MathematicsIn this paper, two-dimensional (2D) heat equations on disjoint rectangles are considered. The solutions are connected by interface Robin’s-type internal conditions.
Miglena N. Koleva, Lubin G. Vulkov
doaj +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Stability Analysis of the Explicit Difference Scheme for Richards Equation. [PDF]
Entropy (Basel), 2020 Liu F, Fukumoto Y, Zhao X.
europepmc +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Perturbational Finite Difference Scheme of Convection-Diffusion Equation
, 2002 The Perturbational Finite Difference (PFD) method is a kind of high-order-accurate compact difference method, But its idea is different from the normal compact method and the multi-nodes method.
Hu LM(胡利民), Gao Z(高智)
core +2 more sources
, 2020 This paper presents a numerical method called the Exact Finite-Difference Scheme for the solution of Ordinary Differential Equations of firstorder. The need for exact finite difference scheme came up due to some shortcomings of the standard methods; in ...
M.Sc. Joshua Sunday
core
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source