Results 231 to 240 of about 4,941,141 (298)

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Visible-Light-Promoted O-Glycosylation Mediated by Halogen Bonding of Selenoglycosides to the Diphenyliodonium Ion. [PDF]

Org Lett
Pradeep V, Mimi A, Descoubes M, Valenzuela EA, Lee S, Milet A, Ragains JR.   +6 more
europepmc   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

An Open Implementation of MSEVB for Reactive Force Field Simulation with Simple Energy-Based Coupling. [PDF]

J Chem Theory Comput
Armstrong BI, Spackman PR, LeBlanc LM, Raiteri P, Gale JD.   +4 more
europepmc   +1 more source

New Insights Into Electron Impact Mass Spectral Fragmentation of Restricted Aromatic Amines. [PDF]

J Mass Spectrom
Dewani R, Rasheed M, Ahmed F, Pervez MK.
europepmc   +1 more source

Electronic State Modulation Interfaced With Interfacial Electric Fields: Ca Site Activation Promoting Photocatalytic Hydrogen Evolution in CdS/Ca₂Co₂O₅ S-Scheme Heterojunction. [PDF]

ChemSusChem
Jin Z, Zhou Z, Ma X, Wu Z, Liu B, Aurbach D, Fornasiero P.   +6 more
europepmc   +1 more source

Problem Formulation Outweighs Loss-Function Choice in Deep-Learning Cervical Vertebral Maturation Staging: A Multi-Seed Study on an Imbalanced Public Benchmark. [PDF]

Diagnostics (Basel)
Tokatlı N.
europepmc   +1 more source

GNSS Spoofing Detection Method Based on the Pseudorange Difference Between Epochs for Single-Antenna Receivers. [PDF]

Sensors (Basel)
Chen S, Li F, Zhang Z, Zhang Q, Wu H, Dong X.   +5 more
europepmc   +1 more source

Smoother Alchemical Transformations via Enveloping Distribution Sampling for Free-Energy Estimation. [PDF]

J Chem Theory Comput
Chen SY, Ruijsenaars E, Hünenberger PH, Riniker S.   +3 more
europepmc   +1 more source