Results 101 to 110 of about 118,141,604 (302)

Sex differences in clinical presentation of systemic lupus erythematosus

, 2019
Objective: Systemic lupus erythematosus (SLE) predominantly affects women, but previous studies suggest that men with SLE present a more severe disease phenotype. In this study, we investigated a large and well-characterized patient group with the aim of
Ramírez Sepúlveda, Jorge I.,, Leonard, Dag,, Rantapää Dahlqvist, Solbritt, DISSECT consortium, Leonard, Dag, Wahren-Herlenius, Marie, Svenungsson, Elisabet,, Svenungsson, Elisabet, Sjöwall, Christopher,, Bengtsson, Christine,, Bengtsson, Anders A., Sjöwall, Christopher, Bengtsson, Anders A,, Ramírez Sepúlveda, Jorge I., Gunnarsson, Iva, Ramírez Sepúlveda, Jorge I,, Rantapää-Dahlqvist, Solbritt,, Nordmark, Gunnel, Bengtsson, Anders A.,, Nordmark, Gunnel,, Rantapää-Dahlqvist, Solbritt, Bolin, Karin, Ramírez Sepúlveda, Jorge I, Gunnarsson, Iva,, Mofors, Johannes,, Mofors, Johannes, Bolin, Karin,, Bengtsson, Anders A, Jönsen, Andreas, Rantapää Dahlqvist, Solbritt,, Rönnblom, Lars, Jönsen, Andreas,, Lund University., Wahren-Herlenius, Marie,, Rönnblom, Lars,, Bengtsson, Christine   +35 more
core   +1 more source

The developmental origins of sex-biased expression in cardiac development [PDF]

, 2019
© 2019 The Author(s). Background: Expression patterns between males and females vary in every adult tissue, even in organs with no conspicuous dimorphisms such as the heart.
Kulathinal, RJ, Karbalaei, Reza, Madzo, J, Kulathinal, Rob|, Deegan, DF, Engel, N, Madzo, Jozef, Karbalaei, R, Engel, Nora, Kulathinal, Rob J., Engel|, Deegan, Daniel F.   +11 more
core   +1 more source

Editorial: Endocrine Diseases of Newborn: Epidemiology, Pathogenesis, Therapeutic Options and Outcome

Frontiers in Pediatrics, 2021
Paula Caroline Midgley, Amanda Lesley Ogilvy-Stuart   +1 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Sex differences in early brain development in a multi-site ASD likelihood cohort

Frontiers in Computational Neuroscience
Biological sex is increasingly recognized as a fundamental dimension of brain organization, yet how it influences early neurodevelopment, particularly autism spectrum disorder (ASD), remains understudied. Using data from the International Infant EEG Data
Gabriel Blanco-Gomez, Gabriel Blanco-Gomez, Julie Scorah, Julie Scorah, Christian O’Reilly, Christian O’Reilly, Stefon van Noordt, Virginia Carter Leno, Virginia Carter Leno, Sara Jane Webb, Mayada Elsabbagh, Mayada Elsabbagh   +11 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source