Results 91 to 100 of about 169,758,901 (249)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

BioQueer: educational narratives on sex and gender—a methodology for developing, implementing, and evaluating an instructional guidebook

Advances in Physiology Education
This study evaluates an educational intervention using a constructivist guidebook developed by the authors to teach human development and sex diversity within physiology education.
Efeh Victorio Monteiro Crempe, Ricardo Murilo Pereira Emídio, Josimary Morais Vasconcelos Oliveira, Caio César Souza Coelho, João Deus de Souza Paiva, Gabrielle Weber, Lucas Garcia Alves Ferreira, Denismar Alves Nogueira, Roseli Soncini   +8 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Progress Report (2014-2015) of the MDB Working Group on Sustainable Transport [PDF]

, 2015
1. In the third year of the Multilateral Development Banks¿1 (MDBs) Joint Statement of 2012, our eight MDBs are on target to meet the goal of the Commitment to Sustainable Transport (hereafter the Rio+20 Commitment) to provide more than $175 billion of ...
Inter-American Development Bank
core   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Differences of sex development and surgical decisions: focus group interviews with health care professionals in Norway

Health Psychology and Behavioral Medicine
Background: Differences of Sex Development (DSD) are congenital conditions where the chromosomal, gonadal and anatomical sex characteristics do not strictly belong to male or female categories, or that belong to both at the same time.
Line Merete Mediå, Lena Fauske, Solrun Sigurdardottir, Kristin J. Billaud Feragen, Anne Waehre   +4 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Editorial: Shared decision making in pediatric differences/disorders of sex development

Frontiers in Urology, 2023
Kristina Suorsa-Johnson, Rebecca K. Delaney, Angela Fagerlin, Angela Fagerlin, David E. Sandberg, David E. Sandberg   +5 more
doaj   +1 more source

Cystoscopy to investigate the prevalence of prostatic utricle cyst in boys with proximal hypospadias and its implications in medium-term follow-up

Frontiers in Pediatrics
PurposeProstatic utricle cyst (PUC) is known to be associated with hypospadias. We aimed to investigate the prevalence of PUC in children with proximal hypospadias by cystoscopy, and risk of symptom development after hypospadias repair.MethodsWe ...
Yuenshan Sammi Wong, Yuenshan Sammi Wong, Yuk Him Tam, Yuk Him Tam   +3 more
doaj   +1 more source

Neurogenin 3 Mediates Sex Chromosome Effects on the Generation of Sex Differences in Hypothalamic Neuronal Development

Frontiers in Cellular Neuroscience, 2014
The organizational action of testosterone during critical periods of development is the cause of numerous sex differences in the brain. However, sex differences in neuritogenesis have been detected in primary neuronal hypothalamic cultures prepared ...
Maria Julia Scerbo, Alejandra eFreire-Regatillo, Carla Daniela Cisternas, Carla Daniela Cisternas, Mabel eBrunotto, Maria Angeles eArevalo, Luis Miguel Garcia-Segura, Maria Julia Cambiasso, Maria Julia Cambiasso   +8 more
doaj   +1 more source