Results 81 to 90 of about 169,758,901 (249)

The persisting presence of absence in female sex development: a critical interdisciplinary reflection

Background For much of the 20th-century, developmental endocrinology was structured around a binary model that positions male differentiation as an active, hormone-driven process and female development as the passive consequence of androgen absence. This
Stammberger, Birgit, Hornig, Nadine, Steinbach, Xenia   +2 more
core   +1 more source

Genetic variants (Lhcgr W495X/+) and environmental toxicants (DEHP) synergistically induce DSD by interfering with steroidogenic gene expression

Biology of Sex Differences
Background Emerging evidence suggests that genetic variants and environmental toxicants may synergistically contribute to DSD. To test this hypothesis, we employed Lhcgr W495X/+ (luteinizing hormone/chorionic gonadotropin receptor) male mice subjected to
Xie Qigen, Xia Kai, Cao Haiming, Xu Zhe, Gao Yong, Deng Chunhua   +5 more
doaj   +1 more source

Sex-dependent Depot Differences in Adipose Tissue Development and Function; Role of Sex Steroids

Journal of Obesity & Metabolic Syndrome, 2017
Men and women are different in their fat mass and distribution pattern. The gynoid-type fat distribution, accumulation in lower-body, is considered to be protective while the android-type accumulation in upper-body, both in abdominal subcutaneous and ...
Mi-Jeong Lee, Susan K. Fried
doaj   +1 more source

Association Between Individualized Education for Kidney Replacement Therapy Modality Selection and Peritoneal Dialysis Initiation: A Cross‐Sectional Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Peritoneal dialysis (PD) is an established home‐based kidney replacement therapy (KRT), but its uptake remains low in Japan. We evaluated whether individualized education in a dedicated outpatient clinic was associated with the initiation of PD.
Yasuko Ito, Ryuichi Yoshimura, Takaki Yamauchi, Yuta Funakoshi, Hirotaka Sonoda, Seiji Kobayashi, Hiroyuki Terawaki, Takafumi Ito   +7 more
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

The effects of intimacy and target sex on direct aggression: Further evidence [PDF]

, 2014
The effects on aggression of target sex and relationship with the target were investigated using self-report data. One hundred and seventy-four participants (115 female) reported on acts of direct aggression in the last two years towards: intimate ...
Cross, Catharine Penelope, Campbell, Anne   +1 more
core   +1 more source

A Pilot Survey of Indian Stakeholders: Parents, Doctors, and Grown-Up Patients of Disorders of Sexual Differentiation on Management Decisions and Associated Gender Dysphoria

Journal of Indian Association of Pediatric Surgeons
Background and Aims: Of late, there are many legal representations from select quarters to halt all medical interventions in children with differences of sex development (DSD).
Simmi K. Ratan, Sujoy Neogi, Md Fahim Ahmad, Kanishka Das, Vijaya Raman, Pradnya S. Bendre, Arka Banerjee, Shilpa Sharma, Himanshu Acharya, Vikesh Agrawal, Ramesh Babu   +10 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Sex differences in the development of experimental diabetic retinopathy

Scientific Reports
This study aimed to characterize the role of female sex in the pathogenesis of diabetic retinopathy. In the retinae of female Ins2Akita-diabetic mice (F-IA), ovariectomized female Ins2Akita-diabetic mice (F-IA/OVX), male Ins2Akita-diabetic mice (M-IA ...
Ying Chen, Andrea Schlotterer, Jihong Lin, Nadine Dietrich, Thomas Fleming, Stefanie Lanzinger, Reinhard W. Holl, Hans-Peter Hammes   +7 more
doaj   +1 more source