Results 101 to 110 of about 2,431,645 (337)

Sex differences in acute and chronic experimental pain models [PDF]

open access: yes, 2010
Sex differences in response to noxious stimuli and in the development of chronic pain have been increasingly recognized and studied in humans and laboratory animals.
Li, Lili
core   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

open access: yesMolecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece   +18 more
wiley   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

open access: yesMolecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia   +9 more
wiley   +1 more source

A Human Gonadal Cell Model From Induced Pluripotent Stem Cells

open access: yesFrontiers in Genetics, 2018
Sertoli cells are main players in the male gonads development and their study may shed light on 46,XY disorders of sex development (DSD). Mature primary Sertoli cells are incapable of proliferating in prolonged in vitro cultures and the available Sertoli
Daniel Rodríguez Gutiérrez   +3 more
doaj   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

open access: yesMolecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed   +10 more
wiley   +1 more source

Sexual Ambiguity—A Social Predicament

open access: yesDr. Sulaiman Al Habib Medical Journal, 2019
Among the diverse clinical manifestations of Disorders of Sex Development (DSD), the ambiguous look of genitalia is the most typical disorder. In this condition, the sex of the newborn cannot be readily differentiated because of atypical appearance of ...
Zair Hassan   +4 more
doaj   +1 more source

ADHD-related sex differences in emotional symptoms across development

open access: green, 2023
Alyssa C. De Ronda   +5 more
openalex   +2 more sources

Why are Male IQ Scores More Variable? [PDF]

open access: yes, 2009
The male female difference in the variance of quantitative traits including IQ can be accounted for by the observation of the concentration of genes involved in brain development on the X chromosome and by the mechanism of sex determination in mammals ...
Bernard Strauss, Jacob Strauss
core   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

open access: yesMolecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto   +8 more
wiley   +1 more source

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