Results 51 to 60 of about 9,147,708 (269)

Differential Dynamic Programming for time-delayed systems [PDF]

2016 IEEE 55th Conference on Decision and Control (CDC), 2016
Trajectory optimization considers the problem of deciding how to control a dynamical system to move along a trajectory which minimizes some cost function. Differential Dynamic Programming (DDP) is an optimal control method which utilizes a second-order approximation of the problem to find the control.
David D. Fan, Evangelos A. Theodorou
openaire   +3 more sources

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Bounds of Different Integral Operators in Tensorial Hilbert and Variable Exponent Function Spaces

Mathematics
In dynamical systems, Hilbert spaces provide a useful framework for analyzing and solving problems because they are able to handle infinitely dimensional spaces.
Waqar Afzal, Mujahid Abbas, Omar Mutab Alsalami   +2 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Multi-exit Kolmogorov–Arnold networks: enhancing accuracy and parsimony

Machine Learning: Science and Technology
Kolmogorov–Arnold networks (KANs) uniquely combine high accuracy with interpretability, making them valuable for scientific modeling. However, it is unclear a priori how deep a network needs to be for any given task, and deeper KANs can be difficult to ...
James Bagrow, Josh Bongard
doaj   +1 more source

Bifurcations in dynamical systems with interior symmetry

, 2010
We propose a definition of interior symmetry in the context of general dynamical systems. This concept appeared originally in the theory of coupled cell networks, as a generalization of the idea of symmetry of a network.
Antoneli, Fernando
core   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Implicit Function Theorems for Non-Differentiable Mappings

, 2006
Sufficient conditions are given for a mapping to be $\gamma$-G inverse differentiable. Constrained implicit function theorems for $\gamma$-G inverse differentiable mappings are obtained. The constraints are either closed convex cones or closed subsets in
Bian, W
core   +1 more source