Results 111 to 120 of about 13,863,270 (332)

Extending the Applicability of a Two-Step Chord-Type Method for Non-Differentiable Operators

Mathematics, 2019
The semi-local convergence analysis of a well defined and efficient two-step Chord-type method in Banach spaces is presented in this study. The recurrence relation technique is used under some weak assumptions.
Ioannis K. Argyros, Neha Gupta, J. P. Jaiswal   +2 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Some Newton’s inequalities on co-ordinates for Riemann–Liouville fractional integrals

Miskolc Mathematical Notes
In this paper, we give an identity involving Riemann–Liouville fractional integrals and partially differentiable function of two variables. Then, we use the newly established identity and prove some new Newton’s type inequalities for differentiable co ...
Fatih Hezenci, Tuba Tunç, Hüseyin Budak, Muhammad Aamir Ali   +3 more
doaj   +1 more source

A Measure Zero UDS in the Heisenberg Group

Bruno Pini Mathematical Analysis Seminar, 2016
We show that the Heisenberg group contains a measure zero set N such that every real-valued Lipschitz function is Pansu differentiable at a point of N.
Andrea Pinamonti, Gareth Speight
doaj   +1 more source

Differentiable even functions

Duke Mathematical Journal, 1943
Not ...
openaire   +3 more sources

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Emulating non-differentiable metrics via knowledge-guided learning: Introducing the Minkowski image loss

Environmental Data Science
The “differentiability gap” presents a primary bottleneck in Earth system deep learning: Since models cannot be trained directly on non-differentiable scientific metrics and must rely on smooth proxies (e.g., MSE), they often fail to capture high ...
Filippo Quarenghi, Ryan Cotsakis, Tom Beucler   +2 more
doaj   +1 more source

Opial inequalities for a conformable ∆-fractional calculus on time scales [PDF]

Mathematica Moravica
In this paper, an Opial-type inequality is introduced on time scale for a conformal ∆-fractional differentiable function of order a, a ∈ (0, 1]. In the case where the certain weight functions are included, one generalization of the Opial inequality is ...
Mirković Tatjana, Bajić Tatjana
doaj   +1 more source

Differential Privacy for Functions and Functional Data

CoRR, 2012
Differential privacy is a framework for privately releasing summaries of a database. Previous work has focused mainly on methods for which the output is a finite dimensional vector, or an element of some discrete set. We develop methods for releasing functions while preserving differential privacy.
Rob Hall 0001, Alessandro Rinaldo, Larry A. Wasserman   +2 more
openaire   +3 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source