Results 71 to 80 of about 1,173,776 (257)
A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
FEBS Letters, EarlyView.Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source
On necessity of L-stationarity in Nonlinear Optimization with a Sparsity Constraint
پژوهشهای ریاضی, 2020 In this paper, we investigate a necessary optimality condition for a specific problem in nonlinear programming, called sparsity constrained problem. This model involves minimizing a continuously differentiable function over a sparsity constraint. We show
Abbas Khademi, Majid Soleimani-damaneh
doaj
Iterative Methods for Pseudocontractive Mappings in Banach Spaces
Abstract and Applied Analysis, 2013 Let E a reflexive Banach space having a uniformly Gâteaux differentiable norm. Let C be a nonempty closed convex subset of E, T:C→C a continuous pseudocontractive mapping with F(T)≠∅, and A:C→C a continuous bounded strongly pseudocontractive mapping with
Jong Soo Jung
doaj +1 more source
Singapore 1:25,000 road map [cartographic material] /
, 2010 Planimetric map of Singapore showing selected buildings, points of interest, and schools.; Some sheets include insets.; Includes list of schools.
Singapore. Ministry of Defence. Mapping Unit.
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The ubiquitin system in normal and infected germinal center B cells
FEBS Letters, EarlyView.The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis +2 more
wiley +1 more source
Extreme non-differentiability of typical Lipschitz mappings
Forum of Mathematics, SigmaWe show that no matter what subset of a normed space is given, a typical 1-Lipschitz mapping into a Banach space is non-differentiable at a typical point of the set in a very strong sense: the set of partial limits of its derivative ratios, which is ...
Michael Dymond, Olga Maleva
doaj +1 more source
Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
Journal of Applied Mathematics, 2012 Let 𝑋 be a uniformly convex Banach space and 𝒮={𝑇(𝑠)∶0≤𝑠0𝐹(𝑇(𝑠))≠∅. Consider the iterative method that generates the sequence {𝑥𝑛} by the algorithm 𝑥𝑛+1=𝛼𝑛𝑓(𝑥𝑛)+𝛽𝑛𝑥𝑛+(1−𝛼𝑛−𝛽𝑛)(1/𝑠𝑛)∫𝑠𝑛0𝑇(𝑠)𝑥𝑛𝑑𝑠,𝑛≥0, where {𝛼𝑛}, {𝛽𝑛}, and {𝑠𝑛} are three sequences ...
Haiqing Wang, Yongfu Su, Hong Zhang
doaj +1 more source
, 1956 Relief shown by spot heights and contours. Contour at 100 ft.; "NMO/56/50"; Also available online http://nla.gov.au/nla.map-vn1758341.
Australia. National Mapping Office.
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Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research
FEBS Letters, EarlyView.What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley +1 more source