Results 91 to 100 of about 822,876 (350)
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
, 1999 Finite-dimensional perturbing operators are constructed using some incomplete information about eigen-solutions of an original and/or adjoint generalized Fredholm operator equation (with zero index).
S.E. Mikhailov, Mikhailov, SE
core +1 more source
Lack of controllability of the heat equation with memory [PDF]
, 2012 We consider a model for the heat equation with memory, which has infinite propagation speed, like the standard heat equation. We prove that, in spite of this, for every T > 0 there exist square integrable initial data which cannot be steered to hit zero ...
Andrei Halanay, Pandolfi, Luciano
core +1 more source
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Mean-field approximation of counting processes from a differential equation perspective
Electronic Journal of Qualitative Theory of Differential Equations, 2016 Deterministic limit of a class of continuous time Markov chains is considered based purely on differential equation techniques. Starting from the linear system of master equations, ordinary differential equations for the moments and a partial ...
Dávid Kunszenti-Kovács, Péter Simon
doaj +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
On the Construction of the Trajectory of a Dynamical System with Initial Data on the Hyperplanes
Известия Иркутского государственного университета: Серия "Математика", 2015 In this paper we consider the problems of correct solvability of the initial value problem for a class of differential equations in Banach spaces. We apply the method of reduction of degenerate differential equation to the regular problems using the ...
O.A. Romanova, N.A. Sidorov
doaj
On the initial value problem for a partial differential equation with operator coefficients
International Journal of Mathematics and Mathematical Sciences, 1980 In the present work it is studied the initial value problem for an equation of the form L∂ku∂tk=∑j=1kLj∂k−ju∂tk−j,where L is an elliptic partial differential operator and (Lj:j=1,…,k) is a family of partial differential operators with bounded operator ...
Mahmoud M. El-Borai
doaj +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source