Results 101 to 110 of about 2,401,333 (312)

Microglial Fkbp5 Impairs Post‐Stroke Vascular Integrity and Regeneration by Promoting Yap1‐Mediated Glycolysis and Oxidative Phosphorylation

Advanced Science, EarlyView.
A post‐stroke perivascular niche of microglia characterized by low expression of M2 markers and elevated glycolysis, oxidative phosphorylation (OXPHOS), and phagocytic activity is identified, which is termed stroke‐activated vascular‐associated microglia (stroke‐VAM).
Yanan Li, Yanmei Qiu, Yunlei Yang, Yanhao Wei, Haokun Peng, Longhai Zeng, Pengcheng Li, Rentang Bi, Bo Hu   +8 more
wiley   +1 more source

Are You Used To It Yet? Braking Performance and Adaptation in a Fixed-base Driving Simulator. [PDF]

, 2003
During braking-to-stop manoeuvres in a fixed-base driving simulator, the paucity of visual and vestibular cues can lead to driver misperception and produce different patterns of braking response between real and simulated driving.
Jamson, A.H., Smith, P.
core  

The First Day in the Life of a Magnetar: Evolution of the Inclination Angle, Magnetic Dipole Moment and Braking Index of Millisecond Magnetars During Gamma-Ray Burst Afterglows

, 2019
The afterglow emission of some gamma-ray bursts (GRBs) show a shallow decay (plateau) phase implying continuous injection of energy. The source of this energy is very commonly attributed to the spin-down power of a nascent millisecond magnetar.
Andaç, I. Ceyhun, Aygun, Ugur, Ekşi, K. Yavuz, Mus, Sinem Sasmaz, Çıkıntoğlu, Sercan   +4 more
core   +1 more source

Combined Photothermal and mTOR‐Targeted Therapy Overcomes Immune Evasion and Enhances Checkpoint Blockade Efficacy in Metastatic Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
This study reveals that photothermal therapy, while inducing immunogenic cell death in triple‐negative breast cancer, paradoxically activates the oncogenic mTOR pathway to drive immune evasion. To counter this, a smart nanocomposite is engineered to co‐deliver localized hyperthermia and mTOR inhibition.
Yujie Zhao, Jing Yu, Xin Wang, Xu Liu, Fengli Zuo, Tianyue Xu, Leyi Tang, Ling Xiong, Li Li, Huifang Li, Xiaoting Chen, Guang Yang, Jing Jing, Xiaowei Liu   +13 more
wiley   +1 more source

Loss of SOCS1 in Donor T Cells Exacerbates Intestinal GVHD by Driving a Chemokine‐Dependent Pro‐Inflammatory Immune Microenvironment

Advanced Science, EarlyView.
T cell‐specific Socs1 knockout leads to inflammatory differentiation of CD8+ T cells, prompting the STAT1/2 complex to drive the activation of Ccl5, Ccr5, and Cxcr3, and promoting the skewing of monocytes toward a pro‐inflammatory M1 macrophage lineage.
Zhigui Wu, Bixia Wang, Xinya Jiang, Fangqing Zhang, Qianqian Huang, Xinyi Wu, Shuang Fan, Qi Zhang, Jingrui Zhou, Jianing Tang, Xiao‐Dong Mo, Yu Wang, Ying‐Jun Chang, Huidong Guo, Xiao‐Jun Huang   +14 more
wiley   +1 more source

Research on Path Tracking Fault-Tolerant Control Strategy for Intelligent Commercial Vehicles Based on Brake Actuator Failure

Actuators
With the development of safety technologies for intelligent commercial vehicles, electronic pneumatic braking systems (EBSs) have been widely used. However, EBS actuators may fail during vehicle operation and thus create safety problems. For this reason,
Guanjie Cui, Chunjiang Bao, Mingjie Guo, Yahui Xu, Yelin He, Jian Wu   +5 more
doaj   +1 more source

A New Principle for Initial Traveling Wave Active Power Differential Busbar Protection

IEEE Access, 2019
To avoid the impact of the transient saturation of a current transformer, a fast busbar protection method based on the initial traveling wave integrated active power differential principle is proposed in this paper.
Hao Wu, Xingxing Dong, Qiaomei Wang
doaj   +1 more source

A Trypsin‐Like Serine Protease ZmNAL1a Fine‐Tunes Maize Floral Transition and Flowering Time

Advanced Science, EarlyView.
This study identifies a trypsin‐like serine protease, ZmNAL1a, that moves from leaves to the shoot apical meristem. ZmNAL1a promotes the floral transition by degrading TOPLESS‐like corepressor REL2, which thereby enhances the expression of key flowering genes through elevating histone acetylation and relieving REL2–ZmEREBP147‐mediated transcriptional ...
Nan Li, Qiang Ning, Zhen Li, Qian Zhang, Peilu Zhu, Jimin Zhan, Yunfu Li, Zhen Li, Liang Dong, Qing Xiong, Jiahao Liao, Jie Liu, David Jackson, Munenori Kitagawa, Zuxin Zhang, Lei Liu   +15 more
wiley   +1 more source

Proper-Motion Measurements with the VLA. II. Observations of Twenty-eight Pulsars

, 2003
Using the Very Large Array, we have measured the proper motions of twenty-eight radio pulsars. On average, the pulsars studied are fainter and more distant than those studied in earlier work, reducing the selection biases inherent in surveys restricted ...
A. S. Fruchter, Fomalont E. B., Fomalont E. B., Gomez G. C., Hansen B., Harrison P. A., Lorimer D. R., Lyne A. G., Lyne A. G., Migliazzo J. M., R. M. Herrnstein, S. E. Thorsett, Stollman G. M., W. F. Brisken, W. M. Goss   +14 more
core   +1 more source

In Situ X‐Ray Tomography and Acoustic Emission Monitoring of Damage Evolution in C/C‐SiC Composites Fabricated by Liquid Silicon Infiltration

Advanced Science, EarlyView.
This study investigates how the internal structure of fiber‐reinforced ceramic composites affects their resistance to damage. By combining 3D X‐ray imaging with acoustic emission monitoring during mechanical testing, it reveals how silicon distribution influences crack formation.
Yang Chen, Renato S. M. Almeida, Stefan Flauder, Guillaume Couégnat, Kamen Tushtev, Jürgen Horvath, Peter Wriggers, Kurosch Rezwan   +7 more
wiley   +1 more source