Results 61 to 70 of about 312,198 (267)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Intramammary bacterial profile and its impact on the number and differential distribution of somatic cells in the context of drying off in dairy cows

Cluj Veterinary Journal
Mastitis remains one of the most significant conditions in dairy cattle farms, with major consequences for animal health and milk quality. The aim of this study was to determine the prevalence of intramammary infections (IMI) and to analyze the ...
Ionela-Delia Ut, Daniel Berean, Simona Ciupe, Stefan Coman, Liviu Bogdan   +4 more
doaj   +1 more source

STUDY ON NORMAL HRMATOLOGICAL VALUES OF ARABIAN RACE HORSES

The Iraqi Journal of Veterinary Medicine, 1987
Hematological values for sixty clinically normal Arabian bred race horses of both sexes were estimated.Red cell ,count, hemoglobin concentration, packed cell volume, mean corpuscular volume, mean ‘corpuscular hemoglobin concentration, white cell count ...
A. K.Al-Delaimi‎, A. J. Ghazi‎
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Comparison of Differential Cell Counts in Samples of Broucho Alveolar Lavage in Diagnosis of Patients with and without Tuberculosis

Journal of Mazandaran University of Medical Sciences, 2017
Background and purpose: Identifying the types of immune cells in patients with tuberculosis (TB) including single-core and multi-core is of great benefit in control and treatment of these patients.
AbbasAli Niazi, NezarAli Molaei, Alireza DashiPour, Amin Rashki Ghaleno, Elahe naz Parsi mood   +4 more
doaj  

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Usefulness of differential somatic cell count for udder health monitoring: Identifying referential values for differential somatic cell count in healthy quarters and quarters with subclinical mastitis

Journal of Dairy Science
: Mastitis, an inflammation of the udder primarily caused by an IMI, is one of the most common diseases in dairy cattle. Somatic cell count has been widely used as an indicator of udder inflammation, assisting in the detection of subclinical mastitis ...
Mariana Fonseca, Daryna Kurban, Jean-Philippe Roy, Débora E. Santschi, Elouise Molgat, Danchen Aaron Yang, Simon Dufour   +6 more
doaj   +1 more source