Results 71 to 80 of about 330,789 (295)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Comparison of two optical-density-based methods and a plate count method for estimation of growth parameters of Bacillus cereus

, 2010
Quantitative microbiological models predicting proliferation of microorganisms relevant for food safety and/or food stability are useful tools to limit the need for generation of biological data through challenge testing and shelf-life testing.
L. G. M. Gorris, Reij, M.W., M. W. Reij, Gorris, L.G.M., H. Joosten, Joosten, H., Zwietering, M.H., E. G. Biesta-Peters, Biesta-Peters, E.G., M. H. Zwietering   +9 more
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Impact of Storage Conditions on Bronchoalveolar Lavage Fluid Analysis: A Human Study

Diagnostics
Background: Bronchoalveolar lavage fluid (BALF) analysis is essential for the accurate diagnosis and management of interstitial lung diseases (ILDs). Despite established guidelines, variability in sample handling may affect diagnostic accuracy.
Yu Shionoya, Kanae Maruyama, Takeshi Kawasaki, Mayumi Ono, Yushi Murai, Ryutaro Hirama, Dai Horiuchi, Noriko Sakuma, Shinsuke Kitahara, Shun Sato, Kohei Takahashi, Yoshihito Ozawa, Takuji Suzuki   +12 more
doaj   +1 more source

Impact of bronchoalveolar lavage lymphocytosis on the effects of anti-inflammatory therapy in idiopathic non-specific interstitial pneumonia, idiopathic pleuroparenchymal fibroelastosis, and unclassifiable idiopathic interstitial pneumonia

Respiratory Research, 2021
Background Idiopathic non-specific interstitial pneumonia (iNSIP), idiopathic pleuroparenchymal fibroelastosis (iPPFE), and unclassifiable idiopathic interstitial pneumonia (IIP) are IIPs with chronic fibrotic phenotypes, and unlike idiopathic pulmonary ...
Akira Yamagata, Machiko Arita, Hiromasa Tachibana, Fumiaki Tokioka, Chikatoshi Sugimoto, Hiromitsu Sumikawa, Tomonori Tanaka, Hideki Yasui, Tomoyuki Fujisawa, Yutaro Nakamura, Takafumi Suda, Tadashi Ishida   +11 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Development of Mid-Infrared Spectroscopy (MIR) Diagnostic Model for Udder Health Status of Dairy Cattle

Animals
The somatic cell count (SCC) and differential somatic cell count (DSCC) are proxies for the udder health of dairy cattle, regarded as the criterion of mastitis identification with healthy, suspicious mastitis, mastitis, and chronic/persistent mastitis ...
Xiaoli Ren, Chu Chu, Xiangnan Bao, Lei Yan, Xueli Bai, Haibo Lu, Changlei Liu, Zhen Zhang, Shujun Zhang   +8 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Intramammary bacterial profile and its impact on the number and differential distribution of somatic cells in the context of drying off in dairy cows

Cluj Veterinary Journal
Mastitis remains one of the most significant conditions in dairy cattle farms, with major consequences for animal health and milk quality. The aim of this study was to determine the prevalence of intramammary infections (IMI) and to analyze the ...
Ionela-Delia Ut, Daniel Berean, Simona Ciupe, Stefan Coman, Liviu Bogdan   +4 more
doaj   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source