Results 81 to 90 of about 1,393,040 (356)
Molecular Oncology, EarlyView.The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine +10 more
wiley +1 more source
Differential Diagnosis of Tremor [PDF]
, 2008 The most common tremor in primary care is an exaggerated physiologic tremor, followed by essential tremor and tremors caused by Parkinson's disease. (Strength of Recommendation [SOR]: C, based on extrapolation from a prospective cohort study of patients ...
Kelsberg, Gary +2 more
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Optimum imaging for inverted papilloma [PDF]
, 2000 Inverted papilloma is the most common benign tumour of the nose and paranasal sinuses, and usually arises in the lateral wall of the nasal cavity and the middle meatus.
Howard, D, Lloyd, G, Lund, VJ, Savy, L
core +1 more source
Molecular Oncology, EarlyView.The COMBAT classification system, developed through multi‐omics integration, stratifies adult patients with B‐cell acute lymphoblastic leukemia(B‐ALL) into three molecular subtypes with distinct surface antigen patterns, immune landscape, methylation patterns, biological pathways and prognosis.
Yang Song +11 more
wiley +1 more source
Meta-heuristic algorithms in car engine design: a literature survey [PDF]
, 2015 Meta-heuristic algorithms are often inspired by natural phenomena, including the evolution of species in Darwinian natural selection theory, ant behaviors in biology, flock behaviors of some birds, and annealing in metallurgy.
Tayarani-N, Mohammad-H. +2 more
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Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma
Molecular Oncology, EarlyView.GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski +19 more
wiley +1 more source
Differential Diagnosis of Glaucoma
, 2019 Glaucoma is the most commonly acquired visual neuropathy and the main cause of irreversible loss of vision.It is characterized by degeneration of retinal ganglion cells resulting in morphology changes of the optic nerve head (ONH). It may be asymptomatic even at an advanced stage, so the diagnosis is often delayed.
Tzamouranis, Dorotheos Dimitrios +1 more
openaire +1 more source
Oral ulcers: Differential diagnosis and treatment [PDF]
, 2017 Las úlceras orales suelen ser muy dolorosas y son motivo de consulta frecuente. Entre sus causas destacan procesos infecciosos, neoplasias, enfermedades gastrointestinales, alteraciones sanguíneas, enfermedades reumatológicas, enfermedades inmunológicas,
Chimenos Küstner, Eduardo +2 more
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Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma
Molecular Oncology, EarlyView.The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias +12 more
wiley +1 more source
A rare cause of recurrent spontaneous pneumothorax: Birt-hogg-dube syndrome [PDF]
, 2018 Birt-Hogg-Dube (BHD) syndrome is an unusual disorder characterized by the triad of cutaneous lesions, renal tumors and lung cysts. In cases with BHD syndrome, the frequency of recurrent pneumothorax is increased due to presence of multiple lung cysts. It
Demirci, M. +3 more
core +1 more source