Results 121 to 130 of about 1,028,381 (308)

Pharmacogenomic implications of the differential distribution of CYP2C9 metabolic phenotypes among Latin American populations. [PDF]

Front Pharmacol, 2023
Suarez-Kurtz G.
europepmc   +1 more source

Differentiable stochastic halo occupation distribution

Monthly Notices of the Royal Astronomical Society
ABSTRACT In this work, we demonstrate how differentiable stochastic sampling techniques developed in the context of deep reinforcement learning can be used to perform efficient parameter inference over stochastic, simulation-based, forward models.
Benjamin Horowitz, ChangHoon Hahn, Francois Lanusse, Chirag Modi, Simone Ferraro   +4 more
openaire   +3 more sources

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Differential Transformation Method for Temperature Distribution in a Radiating Fin

, 2011
Radiating extended surfaces are widely used to enhance heat transfer between a primary surface and the environment. In this paper, the differential transformation method (DTM) is proposed for solving nonlinear differential equation of temperature ...
M. Rahimi, Ganji Domairry, Rahimi, M., Barari, Amin, M. J. Hosseini, Amin Barari, Domairry, G., Hosseini, M. J.   +7 more
core   +1 more source

Characterizing the differential distribution and targets of Sumo1 and Sumo2 in the mouse brain. [PDF]

iScience, 2023
Suk TR, Nguyen TT, Fisk ZA, Mitkovski M, Geertsma HM, Parmasad JA, Heer MM, Callaghan SM, Benseler F, Brose N, Tirard M, Rousseaux MWC.   +11 more
europepmc   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Field Synergy Analysis and Fluid Flow Optimization of Tundish for Six Strands

Teshugang, 2009
The relation between distribution of temperature and fluid flow field in tundish for concasting has been analyzed by using theory of field synergy and the distribution of temperature and fluid flow field in a tundish for six strands at a steel works was ...
张美杰, 林小龙, 黄奥, 汪厚植, 顾华志   +4 more
doaj  

Differential Distribution of Brain Metastases from Non-Small Cell Lung Cancer Based on Mutation Status. [PDF]

Brain Sci, 2023
Chen BT, Jin T, Ye N, Chen SW, Rockne RC, Yoon S, Mambetsariev I, Daniel E, Salgia R.   +8 more
europepmc   +1 more source

Distributions for Compositionally Differentiating Parametric Discontinuities

Proceedings of the ACM on Programming Languages
Computations in physical simulation, computer graphics, and probabilistic inference often require the differentiation of discontinuous processes due to contact, occlusion, and changes at a point in time. Popular differentiable programming languages, such as PyTorch and JAX, ignore discontinuities during differentiation.
Jesse Michel, Kevin Mu, Xuanda Yang, Sai Praveen Bangaru, Elias Rojas Collins, Gilbert Bernstein, Jonathan Ragan-Kelley, Michael Carbin, Tzu-Mao Li   +8 more
openaire   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source