Results 141 to 150 of about 6,761,743 (311)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Information matrix test An application using Pareto’s original income distribution data

, 2010
This article attempts to apply and interpret the correspondent Identification Matrix test (White, 1982) for a Pareto type I distribution. One of the most cited datasets used by Pareto, England’s income distribution in 1843 and in 1879, is used.
Mattos, Enlinson, Ponczek, Vladimir
core  

Differential Distribution of Tryptophan-Metabolites in Fetal and Maternal Circulations During Normotensive and Preeclamptic Pregnancies. [PDF]

Reprod Sci, 2022
Zhao YJ, Zhou C, Wei YY, Li HH, Lei W, Boeldt DS, Wang K, Zheng J.   +7 more
europepmc   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Employment-Based Health Insurance and Pension Benefits: Trends and Inequalities in Accessibility and Participation, 1987-2001

, 2003
This paper documents changing patterns in employment-based health insurance and pension benefits among private-sector wage and salary workers between 1987 and 2001 and examines the trends by workforce characteristics.
Brady, Peter, Lin, Emily Y.
core  

Linear Differential Equations in Distributions [PDF]

Proceedings of the American Mathematical Society, 1956
openaire   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Testing Special Cases of the GB2 Distribution

We examine the power of hypothesis tests leading to four widely used special cases of the four-parameter generalized beta distribution of the second kind (GB2). These are the Singh-Maddala, Dagum, beta-2 and Fisk distributions.
Hill, R. Carter, Griffiths, William
core  

Macroeconomic Variables and Income Distribution: Conditional Modeling with the generalized Exponential

, 2000
This paper presents a method of examining the effects of macroeconomic variables on the personal distribution of income over time. The approach involves modeling the complete distribution of income in each year using a flexible functional form from the ...
Creedy, John, Bakker, Alex
core  

Differential distribution and genetic determination of eccrine sweat glands and hair follicles in the volar skin of C57BL/6 mice and SD rats. [PDF]

BMC Vet Res, 2022
Chen Z, Zhao J, Yan Y, Zhang L, Du L, Liu X, Cao M, Wang C, Tang Y, Li H.   +9 more
europepmc   +1 more source