Results 151 to 160 of about 1,028,381 (308)

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Differential Approach to Cardioid Distribution

, 2011
Jeffreys (1961) introduced Cardioid distribution and used it to modeling directional spectra of ocean waves.Here an attempt is made to derive pdf of cardioid model as a solution of a second order non homogeneouslinear differential equation having ...
Rao AV, Dattatreya, SVS, Girija, Y, Phani   +2 more
core  

Differential distribution of gene polymorphisms associated with hypercholesterolemia, hypertriglyceridemia, and hypoalphalipoproteinemia among Native American and Mestizo Mexicans. [PDF]

World J Hepatol, 2022
Torres-Valadez R, Roman S, Ojeda-Granados C, Gonzalez-Aldaco K, Panduro A.   +4 more
europepmc   +1 more source

Differentially Private Verification of Distribution Properties

CoRR
A recent line of work initiated by Chiesa and Gur and further developed by Herman and Rothblum investigates the sample and communication complexity of verifying properties of distributions with the assistance of a powerful, knowledgeable, but untrusted prover.
Elbert Du, Cynthia Dwork, Pranay Tankala, Linjun Zhang   +3 more
openaire   +2 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Special and Differential Treatment, The Multilateral Trading System and Economic Development in the 21st Century

This paper was prepared for the joint ICTSD – GP International Dialogue entitled, Making Special & Differential Treatment More Effective and Responsive to Development Needs, held 6 & 7 May 2003, in Chavannes-de-bogis, Switzerland.Economic ...
Singh, Ajit
core   +2 more sources

A new fiber orientation distribution function

, 2017
In this work we introduce the barrier orientation distribution function (ODF) as an alternative to the fiber ODF that can be computed with constrained spherical deconvolution.
Florack, L.M.J., Fuster, A., Dela Haije, T.C.J.   +2 more
core  

Adaptive current differential protection for active distribution networks accommodating high levels of PV integration

Zhejiang dianli
The large-scale integration of photovoltaic （PV） sources into distribution networks alters the differential current and braking current of line differential protection， leading to a risk of maloperation in traditional ratio restraint differential ...
CHEN Shuiyao, XU Feng, PAN Wulue, LI Yuehui, WU Jizeng, LIU Sumei   +5 more
doaj   +1 more source

Differential Distribution of Tryptophan-Metabolites in Fetal and Maternal Circulations During Normotensive and Preeclamptic Pregnancies. [PDF]

Reprod Sci, 2022
Zhao YJ, Zhou C, Wei YY, Li HH, Lei W, Boeldt DS, Wang K, Zheng J.   +7 more
europepmc   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source