Results 91 to 100 of about 5,148,909 (356)

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

ON INITIAL BOUNDARY VALUE PROBLEMS FOR THE DEGENERATE 1D WAVE EQUATION

Journal of Optimization, Differential Equations and Their Applications, 2019
Initial boundary value problems in space-time rectangle for the following linear inhomogeneous degenerate wave equation of the second order smooth coefficient function a(x) vanishes in single points of segment.
Vladimir V. Borsch
doaj   +1 more source

On unified framework for nonlinear grey system models: An integro-differential equation perspective [PDF]

, 2022
Lu Yang, Naiming Xie, Baolei Wei, Xiaolei Wang   +3 more
openalex   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

The Exact Bounded Solution to an Initial Boundary Value Problem for 1D Hyperbolic Equation with Interior Degeneracy. I. Separation of Variables

Journal of Optimization, Differential Equations and Their Applications, 2020
Vladimir L. Borsch, Peter I. Kogut
doaj   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Algebraic Properties of First Integrals for Scalar Linear Third-Order ODEs of Maximal Symmetry

Abstract and Applied Analysis, 2013
By use of the Lie symmetry group methods we analyze the relationship between the first integrals of the simplest linear third-order ordinary differential equations (ODEs) and their point symmetries. It is well known that there are three classes of linear
K. S. Mahomed, E. Momoniat
doaj   +1 more source

ADDENDUM TO ‘A BOLTZMANN CORRECTION’

Journal of Optimization, Differential Equations and Their Applications, 2019
Some implications concerning an unobservable medium whose micro-motion (rotational motion in Faraday vortex tubes) produces magnetic phenomena after Maxwell, used in a previous article on the origin of Maxwell’s equation for the magnetic induction (JODEA,
Vladimir V. Borsch
doaj   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

Fractional Sobolev’s Spaces on Time Scales via Conformable Fractional Calculus and Their Application to a Fractional Differential Equation on Time Scales [PDF]

, 2016
Yanning Wang, Jianwen Zhou, Yongkun Li
openalex   +1 more source