Results 241 to 250 of about 1,466,703 (336)

Hybrid Adaptive Crayfish Optimization with Differential Evolution for Color Multi-Threshold Image Segmentation. [PDF]

Biomimetics (Basel)
Rao H, Jia H, Zhang X, Abualigah L.
europepmc   +1 more source

THE EVOLUTION OF DIFFERENTIATION [PDF]

Journal of Clinical Pathology, 1968
openaire   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

A Differential Evolution-Based Optimized Ensemble for Balanced and Imbalanced Medical Datasets. [PDF]

F1000Res
Das S, Nayak SP, Sahoo B, Champati Rai S.   +3 more
europepmc   +1 more source

Multi-clade co-evolution and differential replication efficiencies of subgroup A avian leukosis virus in Chinese guinea fowl [PDF]

Jian Chen, Xiyue Li, Qi Liu, Minghui Li, Zuhua Yu, Songbiao Chen, Lei He, Ke Ding, Ying Wei   +8 more
openalex   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Genome-wide locus-allele comparison reveals differential evolution dynamics from annual wild to landrace and released cultivar soybeans. [PDF]

Plant Genome
Hu X, He J, Gai J.
europepmc   +1 more source

DXMODE: A dynamic explorative multi-operator differential evolution algorithm for engineering optimization problems

Mohamed Reda, Ahmed Onsy, Amira Y. Haikal, Ali Ghanbari   +3 more
openalex   +1 more source

Differential Evolution with Secondary Mutation Strategies for Long-Term Search [PDF]

Jianyi Peng, Gang Chen
openalex   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source