Results 71 to 80 of about 442,456 (299)
MathematicsIn this study, twelve modified differential evolution algorithms with memory properties and adaptive parameters were proposed to address optimization problems.
Shang-Kuan Chen, Gen-Han Wu, Yu-Hsuan Wu
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Neighbor-Induction and Population-Dispersion in Differential Evolution Algorithm
IEEE Access, 2019 The differential evolution (DE) optimization algorithm predominantly relies on elite individuals and random difference to direct evolution. Although the strategy is clear and easy to implement, identifying a suitable direction for the DE mutation ...
Kun Miao, Ziyang Wang
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Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
NLINLS: a Differential Evolution based nonlinear least squares Fortran 77 program [PDF]
This paper provides the list of Fortran 77 codes of nonlinear least squares using Differential Evolution as the minimizer algorithm. It has been tested on a number of difficult nonlinear least squares problems (taken from NIST, USA including CPC-X ...
Mishra, SK
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Integration of PDEs by differential geometric means
, 2013 We use Vessiot theory and exterior calculus to solve partial differential equations(PDEs) of the type uyy = F(x, y,u,ux,uy,uxx,uxy) and associated evolution equations. These equations are represented by the Vessiot distribution of vector fields.
Prince, Geoff, Tehseen, Naghmana
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Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Well Placement Optimization Using Differential Evolution Algorithm [PDF]
Iranian Journal of Chemistry & Chemical Engineering, 2015 Determining the optimal location of wells with the aid of an automated search algorithm is a significant and difficult step in the reservoir development process.
Saied Afshari +2 more
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Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source