Results 41 to 50 of about 2,302,459 (290)
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
Differential Geometry of Identity Maps: A Survey
, 2020 An identity map idM:M→M is a bijective map from a manifold M onto itself which carries each point of M return to the same point. To study the differential geometry of an identity map idM:M→M, we usually assume that the domain M and the range M ...
Bang-Yen Chen
core +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
A visualization of null geodesics for the bonnor massive dipole
Revista de Matemática: Teoría y Aplicaciones, 2015 In this work we simulate null geodesics for the Bonnor massive dipole metric by implementing a symbolic-numerical algorithm in Sage and Python. This program is also capable of visualizing in 3D, in principle, the geodesics for any given metric. Geodesics
G. Andree Oliva Mercado +3 more
doaj +1 more source
An introduction to differential geometry in econometrics [PDF]
, 2000 In this introductory chapter we seek to cover sufficient differential geometry in order to understand its application to Econometrics. It is not intended to be a comprehensive review of either differential geometric theory, nor of all the applications ...
Salmon, Mark H., Marriott, Paul
core
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Liquid crystal director fields in three-dimensional non-Euclidean geometries
New Journal of Physics, 2020 This paper investigates nematic liquid crystals in three-dimensional curved space, and determines which director deformation modes are compatible with each possible type of non-Euclidean geometry. Previous work by Sethna et al showed that double twist is
Jean-François Sadoc +2 more
doaj +1 more source
Special Math Lecture: Differential geometry [PDF]
, 2020 Differential geometry plays a central role in many physical theory, as for example in classical mechanics, in solid states physics or in general relativity.
RICHARD, Serge
core
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source