Results 61 to 70 of about 746,310 (284)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Advancements in detecting, preventing, and mitigating DDoS attacks in cloud environments: A comprehensive systematic review of state-of-the-art approaches

Egyptian Informatics Journal
This comprehensive study examines cutting-edge strategies for combating Distributed Denial of Service (DDoS) attacks in cloud environments, addressing a critical gap in recent literature. Through a systematic review of the latest advancements, we propose
Mohamed Ouhssini, Karim Afdel, Mohamed Akouhar, Elhafed Agherrabi, Abdallah Abarda   +4 more
doaj   +1 more source

Liquid crystal director fields in three-dimensional non-Euclidean geometries

New Journal of Physics, 2020
This paper investigates nematic liquid crystals in three-dimensional curved space, and determines which director deformation modes are compatible with each possible type of non-Euclidean geometry. Previous work by Sethna et al showed that double twist is
Jean-François Sadoc, Rémy Mosseri, Jonathan V Selinger   +2 more
doaj   +1 more source

Geometry of quadrilateral nets: second Hamiltonian form

, 2008
Discrete Darboux-Manakov-Zakharov systems possess two distinct Hamiltonian forms. In the framework of discrete-differential geometry one Hamiltonian form appears in a geometry of circular net. In this paper a geometry of second form is identified.Comment:
Bazhanov, Bazhanov, Bogdanov, Darboux, Doliwa, Doliwa, Doliwa, Faddeev, Kashaev, Konopelchenko, Sergeev, Sergeev, Sergeev, Sergeev, Sergey M. Sergeev, von Gehlen, Zakharov   +16 more
core   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Design of developable surfaces using the given data points

Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2021
Many products such as ships, buildings, and clothes contain developable surfaces generated by sweeping a straight line along a three-dimensional curve.
Kotaro YOSHIDA, Hidefumi WAKAMATSU, Eiji MORINAGA, Seichiro TSUTSUMI, Takahiro KUBO   +4 more
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Metric connections in projective differential geometry

, 2008
We search for Riemannian metrics whose Levi-Civita connection belongs to a given projective class. Following Sinjukov and Mikes, we show that such metrics correspond precisely to suitably positive solutions of a certain projectively invariant finite-type
A.R. Gover, E. Beltrami, E. Cartan, J. Mikeš, N.S. Sinjukov, T.P. Branson, T.Y. Thomas   +6 more
core   +2 more sources