Results 61 to 70 of about 741,871 (299)
On organizing principles of Discrete Differential Geometry. Geometry of spheres
, 2006 Discrete differential geometry aims to develop discrete equivalents of the geometric notions and methods of classical differential geometry. In this survey we discuss the following two fundamental Discretization Principles: the transformation group ...
Bobenko, Alexander I., Suris, Yuri B.
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Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
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Liquid crystal director fields in three-dimensional non-Euclidean geometries
New Journal of Physics, 2020 This paper investigates nematic liquid crystals in three-dimensional curved space, and determines which director deformation modes are compatible with each possible type of non-Euclidean geometry. Previous work by Sethna et al showed that double twist is
Jean-François Sadoc +2 more
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Molecular determinants of signal transduction in tropomyosin receptor kinases
FEBS Open Bio, EarlyView.Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
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SmallTalk: a novel small‐sized fusion tag for peptide expression and purification
FEBS Open Bio, EarlyView.The SmallTalk fusion tag allows for the efficient expression and purification of soluble recombinant proteins or peptides in Escherichia coli. Testing with SmallTalk‐GFP confirmed that the proteins were soluble and folded correctly, while SmallTalk‐Bin1b maintained its antimicrobial activity against various bacterial isolates. This streamlined workflow
Atika Tariq +3 more
wiley +1 more source
Toric, U(2), and LeBrun metrics
Cubo, 2020 The LeBrun ansatz was designed for scalar-flat K\"ahler metrics with a continuous symmetry; here we show it is generalizable to much broader classes of metrics with a symmetry.
Brian Weber
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Quantum Field Theory and Differential Geometry
, 2008 We introduce the historical development and physical idea behind topological Yang-Mills theory and explain how a physical framework describing subatomic physics can be used as a tool to study differential geometry.
Freedman M. +5 more
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FEBS Open Bio, EarlyView.Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu +5 more
wiley +1 more source
Structural Reliability and Optimization Using Differential Geometric Approaches
Iraqi Journal for Computer Science and MathematicsThis study investigates how differential geometry ideas can be used to effectively carry out structural optimization and reliability analysis. Strong mathematical representations and methods for examining intricate surfaces and forms are provided by ...
Saad Abbas Abed +4 more
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Some aspects of noncommutative differential geometry [PDF]
, 1995 We discuss in some generality aspects of noncommutative differential geometry associated with reality conditions and with differential calculi. We then describe the differential calculus based on derivations as generalization of vector fields, and we ...
Dubois-Violette, Michel
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