Results 221 to 230 of about 126,817 (263)

Neuronal α-synuclein toxicity is the key driver of neurodegeneration in multiple system atrophy. [PDF]

Brain
Wiseman JA, Halliday GM, Dieriks BV.
europepmc   +1 more source

Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity

Molecular Oncology, EarlyView.
Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek, Jenny Sprooten, Abhishek D. Garg   +2 more
wiley   +1 more source

Leaving the Excision Site Open After Complete Excision of a Large Paracervical Leiomyoma With Fumarate Hydratase (FH)-Deficient Morphology May Decrease the Risk of Developing Renal Cell Carcinoma. [PDF]

Cureus
Leung D, Sanjaghsaz H, Subramanyam R.
europepmc   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Functional MRI in Multiple System Atrophy: A Promising Biomarker for Clinical Applications. [PDF]

Neuropsychiatr Dis Treat
Xiao S, Ding Y, Weiss A, Cai L, Wang X, Geng X.   +5 more
europepmc   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Rigid inclusion columns and the composite modulus method for enhancing storage tank foundation bearing capacity. [PDF]

Sci Rep
Sadeghian R, Ardakani ARM, Mohammadnezhad H.   +2 more
europepmc   +1 more source

Specific atrophy patterns distinguish tau and TDP-43 pathology: a longitudinal MRI ante-mortem study. [PDF]

Acta Neuropathol Commun
Salman Y, Goloubeva J, Huyghe L, Quenon L, Tomé SO, Hanseeuw B, Alzheimer’s Disease Neuroimaging Initiative.   +6 more
europepmc   +1 more source

Subungual Epidermoid Inclusions-A Series of 8 Cases and a Review of Literature. [PDF]

J Cutan Pathol
Alnaqshabandi SM, Sharma A, Bakhshwin A, Ronen S, Ko JS, Billings SD.   +5 more
europepmc   +1 more source

Single-nucleus and spatial transcriptomic profiling of human temporal cortex and white matter reveals key associations with AD pathology. [PDF]

Nat Commun
Gaur P, Bryois J, Calini D, Foo LC, Hoozemans JJM, Yadav A, Malhotra D, Menon V.   +7 more
europepmc   +1 more source