Results 51 to 60 of about 322,012 (264)
FEBS Letters, EarlyView.Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley +1 more source
Molecular Oncology, EarlyView.AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou +5 more
wiley +1 more source
Probing the charge of a quantum dot with a nanomechanical resonator
, 2012 We have used the mechanical motion of a carbon nanotube (CNT) as a probe of the average charge on a quantum dot. Variations of the resonance frequency and the quality factor are determined by the change in average charge on the quantum dot during a ...
A. Taspinar +8 more
core +2 more sources
A comparison of two configurations for a dual-resonance cymbal transducer [PDF]
, 2018 The ability to design tuned ultrasonic devices that can be operated in the same mode at two different frequencies has the potential to benefit a range of applications, such as surgical cutting procedures where the penetration through soft then hard ...
Feeney, Andrew, Lucas, Margaret
core +1 more source
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
Low Power Resonant Optical Excitation of an Optomechanical Cavity
, 2010 We demonstrate the actuation of a double beam opto-mechanical cavity with a sinusoidally varying optical input power. We observe the driven mechanical motion with only 200 nW coupled to the optical cavity mode.
Altug +23 more
core +1 more source
Influence of System and Actuator Nonlinearities on the Dynamics of Ring-Type MEMS Gyroscopes
Vibration, 2021 This study investigates the nonlinear dynamic response behavior of a rotating ring that forms an essential element of MEMS (Micro Electro Mechanical Systems) ring-based vibratory gyroscopes that utilize oscillatory nonlinear electrostatic forces.
Ibrahim F. Gebrel, Samuel F. Asokanthan
doaj +1 more source
Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source
Biomimetic microelectronics for regenerative neuronal cuff implants [PDF]
, 2015 Smart biomimetics, a unique class of devices combining the mechanical adaptivity of soft actuators with the imperceptibility of microelectronics, is introduced.
Baunack, Stefan +9 more
core +1 more source
Analysis of main dynamic parameters of split power transmission [PDF]
Transport, 2008 The review carried out had shown one basic approach of split power transmission to the organization of drive which is applied to stepless transmissions of tractors and parallel hybrid cars.
A. Janulevičius, K. Giedra
doaj +2 more sources