Results 61 to 70 of about 323,428 (284)

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Experimental study of the dynamic mechanical responses and failure characteristics of coal under true triaxial confinements

International Journal of Mining Science and Technology, 2023
Investigations on the dynamic mechanical properties and failure mechanisms of coal under in-situ stress is essential for the prevention of dynamic disasters in deep coal mines.
Zhanguo Ma, Pengfei Yan, Shixing Cheng, Peng Gong, Fuzhou Qi, Jianguo Wang   +5 more
doaj   +1 more source

Use of the energy of parametric oscillations to improve drilling indices [PDF]

, 2011
Purpose. Increase of the efficiency of using energy of parametric oscillations within the assembly of drilling string bottom by means of solving nonlinear-parametric equations of a “bit – drive motor – drilled-out rock” system to improve drilling indices.
Bakenov, Chernin, Depouhon, Eren, Ghasemloonia, Ghasemloonia, Gibbs, Heisig, Khajiyeva, Parsian, Patil, Saldivar   +11 more
core   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

转炉倾动装置的优化设计

Jixie chuandong, 2006
Tilting device of converter is the most important mechanical equipment on steel-making. A new type multipoint engagement full suspension flexible gearing is introduced. Primal reducer adopts planet differential load balancing mechanism which can make the
张玉忠, 王铁
doaj  

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Behaviour study of an eccentric pulley transmission system using systemic methods

Dyna, 2019
This paper describes a case study carried out on the behaviour of an eccentric pulley transmission system housed in a manually operated abdominal-intestinal assistant device for human use.
Iñaki Esnal Angulo, Bernabé Hernandis Ortuño   +1 more
doaj   +1 more source

Low Cost, Robust, Environmentally Friendly Geopolymer–Mesoporous Carbon Composites for Efficient Solar Powered Steam Generation [PDF]

, 2018
High-efficiency, environment friendly, renewable energy-based methods of desalination represent attractive and potentially very powerful solutions to the long-standing problem of global water shortage.
Bae, Chen, Chen, Ding, Elliott, Fang, Gao, George, Ghasemi, Guo, He, Hu, Ito, Jiang, Kiomarsipour, Li, Li, Li, Liu, Liu, Liu, Liu, Liu, Lou, Nagata, Ni, Ni, Ren, Selvakumar, Shannon, Sharma, Sharma, Shi, Surwade, Wang, Wang, Wang, Wang, Wang, Wang, Wang, Wu, Xu, Xue, Yang, Yang, Yang, Ye, Yin, Zeng, Zhang, Zhang, Zhang, Zhao, Zhou, Zhu, Zhu, Zhu   +57 more
core   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source