Results 81 to 90 of about 323,428 (284)

Pioglitazone plus (−)‐epigallocatechin gallate: a novel approach to enhance osteogenic performance in aged bone marrow mesenchymal stem cells

FEBS Open Bio, EarlyView.
Aged human bmMSCs are seeded in the scaffold. Osteoblastic induction can slightly increase cell's bone‐forming activity to produce bone‐like tissues, shown as the sporadic xylenol orange‐stained spots (the lower left image). Notably, pioglitazone plus EGCG co‐treatment dramatically increases cell's bone‐forming activity and bone‐like tissue production (
Ching‐Yun Chen, Jia‐Ci Jhang, Chun‐Yi Peng, Quốc Cường Nguyễn, Feng‐Huei Lin, Hung‐Ming Wu, Shankung Lin   +6 more
wiley   +1 more source

Coupling carbon nanotube mechanics to a superconducting circuit

, 2012
The quantum behaviour of mechanical resonators is a new and emerging field driven by recent experiments reaching the quantum ground state. The high frequency, small mass, and large quality-factor of carbon nanotube resonators make them attractive for ...
A Hüttel, A Naik, A O'Connell, C Regal, D García-Sánchez, D Rugar, E Buks, G Liu, G Steele, J Chan, J Chaste, J Clarke, J Cleuziou, J Teufel, J Teufel, K Jensen, K Schwab, M Hatridge, M LaHaye, M Poot, O Usenko, P Jarillo-Herrero, S Etaki, T Rocheleau, V Sazonova, W Liang   +25 more
core   +1 more source

CMS Barrel Pixel Detector Overview [PDF]

, 2007
The pixel detector is the innermost tracking device of the CMS experiment at the LHC. It is built from two independent sub devices, the pixel barrel and the end disks. The barrel consists of three concentric layers around the beam pipe with mean radii of
B. Meier, Broennimann, Ch. Hörmann, D. Kotlinski, H.Chr. Kästli, K. Gabathuler, Kotlinski, Kästli, P. Robmann, R. Horisberger, S. König, S. Streuli, T. Rohe, W. Bertl, W. Erdmann   +14 more
core   +2 more sources

Negative differential resistance in memristive systems: historical evolution, mechanisms and neuromorphic applications of niobium oxide devices

Nanoscale
Elucidates diverse NDR mechanisms, modulation strategies, and historical evolution. Comprehensive review of NDR and its application in niobium oxide systems. Offers insights into NDR-memristor synergy for neuromorphic and low-power circuits.
Hongyi Lu, Shiyu Xie, Weijian Zhang, Yue Chen, Jianming Tao, Chinmayee Mandar Mhaskar, Ayan Roy Chaudhuri, Yingbin Lin, Jiaxin Li, Sanjay Mathur, Zhigao Huang   +10 more
openaire   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Qubit compatible superconducting interconnects

, 2017
We present a fabrication process for fully superconducting interconnects compatible with superconducting qubit technology. These interconnects allow for the 3D integration of quantum circuits without introducing lossy amorphous dielectrics.
Arya, K., Barends, R., Burkett, B., Chen, Yu, Chen, Zijun, Chiaro, B., Dunsworth, A., Fowler, A., Foxen, B., Gidney, C., Giustina, M., Graff, R., Huang, T., Jeffrey, E., Kelly, J., Klimov, P., Lucero, E., Martinis, John M., Megrant, A., Mutus, J. Y., Neeley, M., Neill, C., Quintana, C., Roushan, P., Sank, D., Vainsencher, A., Wenner, J., White, T. C., Yang, Yan, Yu, Anthony   +29 more
core   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Calculation of electrical impedance of oscillating piezoceramic disk in the area of high frequencies

Технічна інженерія, 2020
The relevance of the use of various functional elements of piezoelectronics in power and information systems is due primarily to their high reliability. As a result of research of mathematical model of the real device it is possible to define a specific ...
K.V. Bazilo, V.S. Antoiyuk, L.H. Polonskyi, V.D. Holovnia   +3 more
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source