Results 101 to 110 of about 4,425,780 (307)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Investigation of Magnetic Wall Decoupling for planar Quadrature RF Array coils using Common-Mode Differential-mode Resonators. [PDF]

Proc Int Soc Magn Reson Med Sci Meet Exhib Int Soc Magn Reson Med Sci Meet Exhib, 2022
Payne K, Khan SI, Zhang X.
europepmc   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Pseudo-differential frequency filters operating in current mode

, 2018
This bachelor thesis deals with pseudo-differential frequency filters working in current mode. This thesis further describes different types of frequency filters and their characteristics.
Velič, Ladislav
core   +1 more source

Temperature drift suppression and measurement dead zone elimination in differential MEMS resonant accelerometers using dual-mode operating method

Microsystems & Nanoengineering
This paper proposes a differential mode measurement and control system (DMCS) for differential MEMS resonant accelerometer (DMRA), which operates the differential resonators of the DMRA at different vibration modes.
Bingchen Zhu, Zheng Wang, Liangbo Ma, Zhaoyang Zhai, Kunfeng Wang, Wuhao Yang, Xiaorui Bie, Xudong Zou   +7 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Switchable differential filter using dual‐mode dielectric resonator

Electronics Letters, 2019
This Letter presents a method for designing a switchable differential filter with high performance using dual‐mode dielectric resonator (DR). It consists of a half‐cut dual‐mode DR, four feeding probes and a printed circuit board which is embedded in the
Xiao‐Xiao Yuan, Li‐Heng Zhou, Jian‐Xin Chen   +2 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Generalized mixed-mode S-parameters [PDF]

, 2006
This paper presents an innovative approach to extend the S-parameter definition to multiport networks having conventional single-ended and differential ports, as is the case for operational amplifiers, transformers and baluns.
Ferrero, Andrea Pierenrico, Pirola, Marco   +1 more
core   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source