Results 71 to 80 of about 59,667 (255)
PhotonicsWith the widespread use and increasing importance of few-mode fibers (FMFs), comprehensive dispersion measurement for FMFs with large mode numbers is in urgent demand.
Bingyi Zhao +6 more
doaj +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
IEEE Photonics Journal, 2013 A novel optoelectronic oscillator based on a single bandpass microwave photonic filter (MPF) without any electronic microwave filter is proposed and experimentally demonstrated.
Chenjun Liu, Weiwen Zou, Jianping Chen
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Fast Frequency Regulation Method of PV System Based on Feedforward of VPPT Reference Value
Advanced ElectromagneticsHigh penetration of photovoltaic (PV) generation reduces the frequency regulation margin of power systems because inverter-based resources contribute little inherent inertia.
W. Q. Xie +4 more
doaj +1 more source
Abstract and Applied Analysis, 2013 The paper considers the problem of variable structure control for nonlinear systems with uncertainty and time delays under persistent disturbance by using the optimal sliding mode surface approach.
Jing Lei +3 more
doaj +1 more source
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
Chengshi guidao jiaotong yanjiuObjective Addressing the issues of low control accuracy and poor disturbance rejection in conventional ATO (automatic train operation) speed control algorithms in urban rail transit train operation control systems, a new speed control algorithm is ...
LIANG Huadian, HONG Tianhua, GAO Qi
doaj +1 more source
Molecular Oncology, EarlyView.Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant +11 more
wiley +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source