Results 71 to 80 of about 59,044 (257)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Variable Structure Disturbance Rejection Control for Nonlinear Uncertain Systems with State and Control Delays via Optimal Sliding Mode Surface Approach

Abstract and Applied Analysis, 2013
The paper considers the problem of variable structure control for nonlinear systems with uncertainty and time delays under persistent disturbance by using the optimal sliding mode surface approach.
Jing Lei, Xin Wang, Yu-Mei She, Tian-Jun Zhang   +3 more
doaj   +1 more source

An Optoelectronic Oscillator Based on Carrier-Suppression-Effect-Free Single Bandpass Microwave Photonic Filter

IEEE Photonics Journal, 2013
A novel optoelectronic oscillator based on a single bandpass microwave photonic filter (MPF) without any electronic microwave filter is proposed and experimentally demonstrated.
Chenjun Liu, Weiwen Zou, Jianping Chen
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Research on Speed Tracking Control Algorithm for Urban Rail Transit Trains Based on Sliding Mode and RBF Neural Network

Chengshi guidao jiaotong yanjiu
Objective Addressing the issues of low control accuracy and poor disturbance rejection in conventional ATO (automatic train operation) speed control algorithms in urban rail transit train operation control systems, a new speed control algorithm is ...
LIANG Huadian, HONG Tianhua, GAO Qi
doaj   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

Sliding Mode Control for Uncertain Neutral Delay-Differential Systems.

JSME International Journal Series C, 2002
This paper investigates the problems of stability analysis and sliding mode control for a class of uncertain neutral delay-differential systems. First, we develop a new delay dependent condition such that uncertain neutral systems are not only asymptotically stable but also with a prescribed stability degree.
openaire   +2 more sources

A high CMTI codec circuit based on on-chio transformer isolation

Dianzi Jishu Yingyong
With the development of the third generation of wide bandgap semiconductor materials, new power switches such as GaN and SiC have been widely used, and the fast switching speed of the new power tubes makes the transient voltage dV/dt of the driver switch
Liu Jiajun, Li Fei
doaj   +1 more source