Results 121 to 130 of about 3,790,657 (295)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

A differential protection method for multi-terminal lines in distribution networks based on the alpha plane of current fault components

Zhejiang dianli
To address the challenges in differential protection applications for multi-terminal lines in distribution networks， such as reduced sensitivity， the inability to compensate for capacitive current under no-voltage conditions， and susceptibility of ...
HAN Jin, XU Guangxue, QIU Yutao, XIE Sixian, SUN Yan, GUAN Jiyong, ZHU Zhiyong   +6 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Progress report - Plant Protection and Quarantine Programs.

Report covers fiscal year 1979.Mode of access: Internet.Supersedes: United States. Agricultural Research Service. Plant Protection Division. Annual report - U.S.
United States. Animal and Plant Health Inspection Service. Plant Protection and Quarantine Programs.
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Natural Killer Cells Offer Differential Protection From Leukemia in Chinese Southern Han. [PDF]

Front Immunol, 2019
Deng Z, Zhao J, Cai S, Qi Y, Yu Q, Martin MP, Gao X, Chen R, Zhuo J, Zhen J, Zhang M, Zhang G, He L, Zou H, Lu L, Zhu W, Hong W, Carrington M, Norman PJ.   +18 more
europepmc   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Connecticut Department of Environmental Protection

, 2011
Updated irregularly; Began in 2002?; Title from home page (publisher's Web site, viewed Jan. 10, 2011).; Harvested from the web on 1/10/11Official website of the Connecticut Department of Environmental Protection.

core  

NAP (davunetide) preferential interaction with dynamic 3-repeat Tau explains differential protection in selected tauopathies. [PDF]

PLoS One, 2019
Ivashko-Pachima Y, Maor-Nof M, Gozes I.
europepmc   +1 more source