Results 101 to 110 of about 129,642 (295)

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Angle Control of Independent Drive Differential Steering Wheelset

Journal of Innovation and Development
This study investigates the relative angle control between a single wheelset and the chassis, taking into account the independent rotation of each wheelset in the four-wheel steering chassis with four differential wheelsets. To ensure coordinated and stable chassis motion while adjusting the wheelset angle, it is necessary to account for the impact of ...
Jiaqi Zhang, Cunsheng Zhang, Gaofei Qu
openaire   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Orbital Dynamics of an Oscillating Sail in the Earth-Moon System [PDF]

, 2017
The oscillating sail is a novel solar sail configuration where a triangular sail is released at a deflected angle with respect to the Sun-direction. As a result, the sail will conduct an undamped oscillating motion around the Sun-line due to the offset ...
Ceriotti, Matteo, Heiligers, Jeannette
core  

Differentially Private Steering for Large Language Model Alignment

Aligning Large Language Models (LLMs) with human values and away from undesirable behaviors (such as hallucination) has become increasingly important. Recently, steering LLMs towards a desired behavior via activation editing has emerged as an effective method to mitigate harmful generations at inference-time.
Goel, Anmol, Hu, Yaxi, Gurevych, Iryna, Sanyal, Amartya   +3 more
openaire   +2 more sources

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Feedback control for steering support system based on flatness and particle swarm optimization

Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2016
In this study we give a feedback control method for steering support system. In this method we consider the stability of the path tracking control system under the limitation of steering angle, so that drivers can drive safer and more comfortable.
Michihiro KAWANISHI, Yuta TSUGE, Shi-Jia PEI, Tatsuo NARIKIYO   +3 more
doaj   +1 more source

Probing nonclassicality in an optically-driven cavity with two atomic ensembles

, 2018
The possibility of observing nonclassical features in a physical system comprised of a cavity with two ensembles of two-level atoms has been investigated by considering different configurations of the ensembles with respect to the Node and Antinode of ...
Banerjee, Subhashish, Naikoo, Javid, Pathak, Anirban, Thapliyal, Kishore   +3 more
core   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source