Results 121 to 130 of about 604,284 (310)
PAIR Final Comprehensive Report Part 2: Impact of PAIR on Student Academic Performance [PDF]
, 2011 This report is the second part of a three-part comprehensive report filed by both Dr. Burnaford and Dr. Scripp, as Co-Principal Investigators of the PAIR project.The first report, written by Dr.
Lawrence Scripp
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AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
Multinational firms, market integration and trade structure: what remains of the standard goods hypothesis?. [PDF]
In extending traditional empirical trade models with multinational firms, this paper shows the effect of transferring firm specific technology on the trade structure of host countries.
De Backer, Koenraad, Sleuwaegen, Leo
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pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Horizontal Mergers in Internet [PDF]
Our work concerns the Internet network. We propose to modify the traditional analysis of the theoretical economic literature which emphasizes on the vertical integration among backbones and ISPs, and his difficulties because IBPs have a strongmarket ...
Baranes, E., Cortade, T.
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Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Analysis of uniform binary subdivision schemes for curve design [PDF]
, 1988 The paper analyses the convergence of sequences of control polygons produced by a binary subdivision scheme of the form .0,1,2,...kz,ikj,ifjbm0j1k12ifjam0j1k2if=∈+Σ==++Σ==+ The convergence of the control polygons to a Cu curve is analysed in terms of ...
Dyn, N, Gregory, JA, Levin, D
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