Results 91 to 100 of about 1,742 (133)

The Simplex (Differentiated) Variant of Vulvar Intraepithelial Neoplasia

Dermatologic Surgery, 2004
The simplex (differentiated) variant of vulvar intraepithelial neoplasia is rarely reported. It is regarded as more likely than "classic" carcinoma in situ to be associated with invasion and can be easily mistaken for benign lesions.The objective was to present a case of simplex variant of vulvar intraepithelial neoplasia in a 67-year-old woman that ...
Meng-Yueh, Hsieh, Hung-Wen, Kuo
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Differentiated Vulvar Intraepithelial Neoplasia (VIN)

Pathology Case Reviews, 2005
Abstract: Squamous intraepithelial lesions of the vulva, known as vulvar intraepithelial neoplasia, or VIN, are considered to be precursors of invasive squamous cell carcinoma. About a third of invasive squamous cell carcinomas are associated with human papillomavirus (HPV), but no link with HPV is detected in the remaining two thirds.
Charles Zaloudek, Joseph T. Rabban
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Differentiated vulvar intraepithelial neoplasia has a high-risk of recurrence and progression to invasive vulvar cancer

Gynecologic Oncology, 2021
Objectives: Differentiated vulvar intraepithelial neoplasia (dVIN) is implicated as a precursor to HPV-negative squamous cell carcinoma of the vulva (SCCV). It has a variable clinical course that has not yet been fully characterized. Data on the clinical and histopathologic features of dVIN, risk of recurrence and progression to SCCV is limited.
Jill Roberts, Jessica Dillon, Ilana Cass
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Mass Spectrometry Proteomic Analysis of Four p53 Patterns in Differentiated Vulvar Intraepithelial Neoplasia

Journal of Lower Genital Tract Disease, 2023
Objective The histopathologic diagnostic criteria of differentiated vulvar intraepithelial neoplasia (dVIN), the precursor of human papillomavirus-independent squamous cell carcinoma, are basal atypia, a negative or non–block-positive p16, and a supportive p53 immunohistochemistry (IHC). Several different patterns of supportive
Jamaluddin, M. Fairuz B., Day, Tania, Tanwar, Pradeep S., Marzol, Alexandra, Scurry, James   +4 more
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Classic Vulvar Intraepithelial Neoplasia With Superimposed Lichen Simplex Chronicus: A Unique Variant Mimicking Differentiated Vulvar Intraepithelial Neoplasia

International Journal of Gynecological Pathology, 2019
High-grade vulvar intraepithelial neoplasia, a precursor lesion to vulvar squamous cell carcinoma, is subdivided into 2 types, classic or usual vulvar intraepithelial neoplasia (CVIN) and differentiated vulvar intraepithelial neoplasia (DVIN). CVIN, which is a human papilloma virus (HPV)-dependent lesion, is typically distinguished from DVIN, a p53 ...
Watkins, Jaclyn, Yang, Eric, Crum, Christopher, Herfs, Michael, Gheit, Tarik, Tommasino, Massimo, Nucci, Marisa   +6 more
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Assessment of CK17 as a Marker for the Diagnosis of Differentiated Vulvar Intraepithelial Neoplasia

International Journal of Gynecological Pathology, 2017
Differentiated vulvar intraepithelial neoplasia (dVIN), precursor of vulvar squamous cell carcinoma, is human papilloma virus independent and often found in a background of lichen sclerosus (LS) and lichen simplex chronicus (LSC). Subtle histologic findings make the diagnosis of dVIN difficult, and, although the use of p53 and Ki-67 has been of some ...
Mirna B, Podoll, Naveena, Singh, C Blake, Gilks, Mana, Moghadamfalahi, Mary Ann, Sanders   +4 more
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Differentiated (Simplex) Vulvar Intraepithelial Neoplasia: A Case Report and Review of the Literature

The American Journal of Dermatopathology, 2011
Differentiated (simplex) vulvar intraepithelial neoplasia (VIN) is an uncommon variant of VIN characterized by highly differentiated morphology, making it a potential diagnostic pitfall. It may arise in the background of lichen sclerosus, and unlike most VIN, is not causally associated with human papilloma virus infection.
Janis M, Taube, Joanna, Badger, Christina S, Kong, Soheil S, Dadras   +3 more
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Distinguishing Erosive Lichen Planus From Differentiated Vulvar Intraepithelial Neoplasia

Journal of Lower Genital Tract Disease, 2016
Erosive lichen planus (LP) and differentiated vulvar intraepithelial neoplasia (dVIN) may display overlapping histopathologic features.We searched the local pathology database for vulvar biopsies reported as dVIN or erosive vulvitis during 2011 to 2013 inclusive.
Day, Tania, Bowden, Nikola, Jaaback, Ken, Otton, Geoff, Scurry, James   +4 more
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Vulvar Intraepithelial Neoplasia of the Simplex (Differentiated) Type

The American Journal of Surgical Pathology, 2000
The simplex (differentiated) variant of vulvar intraepithelial neoplasia (VIN) has not been well characterized. The authors studied the clinicopathologic features of 12 cases of simplex VIN and obtained follow-up data to assess its relationship to vulvar invasive squamous cell carcinoma (InvSCC).
B, Yang, W R, Hart
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Differentiating Vulvar Intraepithelial Neoplasia From Nonneoplastic Epithelial Disorders

Obstetrical & Gynecological Survey, 1999
To determine the effectiveness of the toluidine blue test in the differentiation of vulvar intraepithelial neoplasia (VIN) and nonneoplastic epithelial disorders (NNEDs).This retrospective clinical study included all women with VIN (n = 24) and NNED (n = 72) referred to a vulvar clinic at a university hospital during a two-year period.
E A, Joura, H, Zeisler, A, Lösch, M O, Sator, S, Müllauer-Ertl   +4 more
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