Results 101 to 110 of about 1,742 (133)

p53/CK17 Dual Stain Improves Accuracy of Distinction Between Differentiated Vulvar Intraepithelial Neoplasia and Its Mimics

International Journal of Gynecological Pathology, 2021
Accurate diagnosis of differentiated vulvar intraepithelial neoplasia (dVIN) is challenging, in part due to the sometimes subtle nature of its atypia. Many dVIN lesions demonstrate aberrant p53 staining; however, staining patterns overlap between dVIN and benign/reactive entities.
Emily R, McMullen-Tabry, Shula A, Schechter, Grace Y, Wang, Andrew P, Sciallis, Steven M, Hrycaj, May P, Chan, Stephanie L, Skala   +6 more
openaire   +2 more sources

PRAME Expression in HPV-associated and Differentiated Vulvar Intraepithelial Neoplasia–associated Vulvar Squamous Neoplasia

International Journal of Gynecological Pathology
Preferentially expressed antigen in melanoma (PRAME) immunohistochemistry was initially used diagnostically in melanoma but is increasingly evaluated across malignancies for diagnostic, prognostic, and therapeutic purposes. PRAME protein acts as a dominant repressor of retinoic acid signaling and may help stratify patients for ...
Eyas Alzayadneh, Sarah E. Gradecki, Landon K. Hobbs, William J. Kane, Anne M. Mills, Shyam S. Raghavan, Taylor M. Jenkins   +6 more
openaire   +1 more source

HPV-independent Differentiated Vulvar Intraepithelial Neoplasia (dVIN) is Associated With an Aggressive Clinical Course

International Journal of Gynecological Pathology, 2017
Differentiated vulvar intrapeithelial neoplasia (dVIN) is an human papillomavirus (HPV)–independent precursor of squamous cell carcinoma (SCC), and the aim of this study was to better characterize its natural history. Cases of dVIN were identified from the pathology archives.
Jessica N, McAlpine, So Youn, Kim, Ardalan, Akbari, Sima, Eshragh, Miriam, Reuschenbach, Magnus, von Knebel Doeberitz, Elena S, Prigge, Suzanne, Jordan, Naveena, Singh, Dianne M, Miller, C Blake, Gilks   +10 more
openaire   +2 more sources

The Natural History of Vulvar Intraepithelial Neoplasia, Differentiated Type: Evidence for Progression and Diagnostic Challenges

International Journal of Gynecological Pathology, 2016
Squamous cell carcinoma of the vulva (SCCV) develops through either human papillomavirus (HPV)-dependent or HPV-independent pathways. Approximately 60% of SCCV arise independently of HPV, commonly in a background of an inflammatory dermatosis, particularly lichen sclerosus.
Susan M, Bigby, Lois J, Eva, Kah Leng, Fong, Ronald W, Jones   +3 more
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Vulvar intraepithelial neoplasia and vulvar squamous cell carcinoma: differential dermoscopic features in a case series, and a progression model

Clinical and Experimental Dermatology, 2018
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Vaccari, S., Barisani, A., Preti, E. P., Dika, E., Fanti, P. A., Patrizi, A., Tosti, G.   +6 more
openaire   +3 more sources

Differentiated Vulvar Intraepithelial Neoplasia: What Criteria Do We Use in Practice?

Journal of Lower Genital Tract Disease, 2016
Objectives We sought to recognize the working diagnostic criteria for differentiated vulvar intraepithelial neoplasia (dVIN) among expert pathologists in the field. We also sought the frequency of definitive diagnosis, terminology of equivocal lesions, and views on dVIN’s biological significance.
Jason C, Reutter, Ruth A, Walters, M Angelica, Selim   +2 more
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A Case of Basaloid Differentiated Vulvar Intraepithelial Neoplasia

Journal of Lower Genital Tract Disease, 2023
Courtney L, O'Keefe, Luisa Y A, Watts, Jill I, Allbritton   +2 more
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Presence and type of oncogenic human papillomavirus in classic and in differentiated vulvar intraepithelial neoplasia and keratinizing vulvar squamous cell carcinoma

Journal of Medical Virology, 2005
AbstractThe presence and type of oncogenic papillomavirus (HPV) in classic warty/basaloid vulvar intraepithelial neoplasia and in differentiated vulvar intraepithelial neoplasia and keratinizing vulvar squamous cell carcinoma was investigated using three techniques, that is, histology, in situ hybridization, and PCR–ELISA.
BONVICINI, FRANCESCA, Venturoli S, AMBRETTI, SIMONE, PATERINI, PAOLA, SANTINI, DONATELLA, CECCARELLI, CLAUDIO, ZERBINI, MARIALUISA, MUSIANI, MONICA   +7 more
openaire   +3 more sources

DIFFERENTIATED VULVAR INTRAEPITHELIAL NEOPLASIA: A CLINICAL EXAMPLE OF INTERDISCIPLINARY PATIENT MANAGEMENT

Transbaikalian Medical Bulletin
Differentiated vulvar intraepithelial neoplasia (dVIN) is an obligate precancer, develops during chronic vulvodermatoses, such as lichen sclerosus and lichen simplex chronicus. The epidemiological, clinical, pathomorphological, diagnostic, and prognostic features of dVIN are discusses.
E. V. Kayukova, V. A. Dudarev, T. М. Barkan, A. A. Zajkina   +3 more
openaire   +1 more source

HPV-negative Vulvar Intraepithelial Neoplasia (VIN) With Basaloid Histologic Pattern

American Journal of Surgical Pathology, 2009
Vulvar intraepithelial neoplasia (VIN) is classified into 2 clinicopathologic subtypes, classic, related to human papillomavirus (HPV) infection and affecting relatively young women, and simplex (differentiated), negative for HPV and affecting elderly women.
Jaume, Ordi, Maria, Alejo, Victòria, Fusté, Belen, Lloveras, Marta, Del Pino, Immaculada, Alonso, Aureli, Torné   +6 more
openaire   +2 more sources