Multi‐layered stochasticity and paracrine signal propagation shape the type‐I interferon response
Molecular Systems Biology, 2012 The cellular recognition of viruses evokes the secretion of type‐I interferons (IFNs) that induce an antiviral protective state. By live‐cell imaging, we show that key steps of virus‐induced signal transduction, IFN‐β expression, and induction of IFN ...
Ulfert Rand +10 more
doaj +1 more source
Towards differentiation and integration between Hopf algebroids and Lie algebroids
, 2020 In this paper we set up the foundations around the notions of formal differentiation and formal integration in the context of commutative Hopf algebroids and Lie-Rinehart algebras.
Ardizzoni, Alessandro +2 more
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From omics to AI—mapping the pathogenic pathways in type 2 diabetes
FEBS Letters, EarlyView.Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan +2 more
wiley +1 more source
ERBIN limits epithelial cell plasticity via suppression of TGF‐β signaling
FEBS Letters, EarlyView.In breast and lung cancer patients, low ERBIN expression correlates with poor clinical outcomes. Here, we show that ERBIN inhibits TGF‐β‐induced epithelial‐to‐mesenchymal transition in NMuMG breast and A549 lung adenocarcinoma cell lines. ERBIN suppresses TGF‐β/SMAD signaling and reduces TGF‐β‐induced ERK phosphorylation.
Chao Li +3 more
wiley +1 more source
Morphology regulation in vascular endothelial cells
Inflammation and Regeneration, 2018 Morphological change in endothelial cells is an initial and crucial step in the process of establishing a functional vascular network. Following or associated with differentiation and proliferation, endothelial cells elongate and assemble into linear ...
Kiyomi Tsuji-Tamura, Minetaro Ogawa
doaj +1 more source
ELECTROPHORESIS OF DIPHTHERIA BACILLI II. MICRO-ELECTROPHORESIS AND THE DIFFERENTIATION OF VIRULENT AND NON-VIRULENT DIPHTHERIA BACILLI [PDF]
, 1928 L. B. Jensen +3 more
openalex +1 more source
Cell‐free DNA aneuploidy score as a dynamic early response marker in prostate cancer
Molecular Oncology, EarlyView.mFast‐SeqS‐based genome‐wide aneuploidy scores are concordant with aneuploidy scores obtained by whole genome sequencing from tumor tissue and can predict response to ARSI treatment at baseline and, at an early time point, to ARSI and taxanes. This assay can be easily performed at low cost and requires little input of cfDNA. Cell‐free circulating tumor
Khrystany T. Isebia +17 more
wiley +1 more source
Modelling Torsade de Pointes arrhythmias in vitro in 3D human iPS cell-engineered heart tissue
Nature Communications, 2017 Torsade de Pointes (TdP) is a life-threatening ventricular arrhythmia often caused by drugs. In response to an urgent need for human tissue TdP models, here the authors describe a 3D human iPS cell-engineered heart tissue that generates TdP in response ...
Masahide Kawatou +6 more
doaj +1 more source
Costly horizontal differentiation [PDF]
We study the effect of quadratic differentiation costs in the Hotelling model of endogenous product differentiation. The equilibrium location choices are found to depend on the magnitude of the differentiation costs (relatively to the transportation ...
Joana Pinho, João Correia-da-Silva
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Insurance company financial management by optimising premium level: the case of Poland [PDF]
, 2004 The article, which falls within the terms of reference of insurance risk analysis, presents research on the death risk regional differentiation and its influence on the level of insurance and social security premiums.
Sliwinski, A.
core