Results 161 to 170 of about 6,101,774 (389)

Targeted protein degradation in oncology: novel therapeutic opportunity for solid tumours?

open access: yesMolecular Oncology, EarlyView.
Current anticancer therapies are limited by the occurrence of resistance and undruggability of most proteins. Targeted protein degraders are novel, promising agents that trigger the selective degradation of previously undruggable proteins through the recruitment of the ubiquitin–proteasome machinery. Their mechanism of action raises exciting challenges,
Noé Herbel, Sophie Postel‐Vinay
wiley   +1 more source

Integrated GC-MS and UPLC-ESI-QTOF-MS based untargeted metabolomics analysis of in vitro raised tissues of Digitalis purpurea L

open access: yesFrontiers in Plant Science
Digitalis purpurea L. is one of the important plant species of Nilgiris, Kashmir and Darjeeling regions of India, belonging to the family Plantaginaceae, with well-known pharmacological applications.
Yashika Bansal   +7 more
doaj   +1 more source

Aberrant expression of nuclear prothymosin α contributes to epithelial‐mesenchymal transition in lung cancer

open access: yesMolecular Oncology, EarlyView.
Nuclear prothymosin α inhibits epithelial‐mesenchymal transition (EMT) in lung cancer by increasing Smad7 acetylation and competing with Smad2 for binding to SNAI1, TWIST1, and ZEB1 promoters. In early‐stage cancer, ProT suppresses TGF‐β‐induced EMT, while its loss in the nucleus in late‐stage cancer leads to enhanced EMT and poor prognosis.
Liyun Chen   +12 more
wiley   +1 more source

Geometric and Physical Interpretation of Fractional Integration and Fractional Differentiation

open access: yes, 2001
A solution to the more than 300-years old problem of geometric and physical interpretation of fractional integration and differentiation (i.e., integration and differentiation of an arbitrary real order) is suggested for the Riemann-Liouville fractional ...
Podlubny, Igor
core   +2 more sources

Does Porphyromonas gingivalis truly inhibit the oral carcinogenesis?

open access: yesMolecular Oncology, EarlyView.
 
Chen‐xi Li, Zhong‐cheng Gong
wiley   +1 more source

Osf2/Cbfa1: A Transcriptional Activator of Osteoblast Differentiation

open access: yesCell, 1997
P. Ducy   +4 more
semanticscholar   +1 more source

Treatise on Differentiation

open access: yes
This treatise develops a unified ontological framework grounded in the principle of differentiation. Each level of structure, from physical persistence to conscious reflection and ethical relation, is traced to acts of differentiation stabilized across recursive scenes.
openaire   +1 more source

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