Results 121 to 130 of about 293,677 (256)

Analytical Sensitivity Analysis of Dynamic Problems with Direct Differentiation of Generalized-α Time Integration

Machines
In this paper, the direct differentiation of generalized-α time integration is derived, equations are introduced and results are shown. Although generalized-α time integration has found usage, the derivation and the resulting equations for the analytical
Erich Wehrle, Veit Gufler
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Increased Differentiation or Stronger Uniformity [PDF]

closer cooperation; differentiation; institutions; integration theory; law; majority voting; Single Market; subsidiarity; Treaty on European Union ...
Claus-Dieter Ehlermann
core  

Illiberal Concept of EU Reform: Polish Conservative Ideologists in the Debate on Differentiated Integration

Politeja
Differentiated integration is the outcome of intergovernmental negotiations resulting from states’ diverse preferences on the European Union’s systemic model.
Piotr Tosiek
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Differentiation of self and marital adjustment within the Asian Indian American population [PDF]

, 2001
Plan BThis study was designed to examine the universality of Murray Bowen's theory of differentiation of self. Bowen believed that the level of differentiation a person achieves in their family of origin plays a crucial role in the types of adult ...
Bhatt, Pooja
core  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

'Integration through Law' Revisited: The Making of the European Polity [PDF]

, 2012
The contributors of this edited collection revisit one of the first academic projects to concepualise and study legal integration, the 'Integration through Law' project, started at the European University Institute, Florence, in 1978 and directed by ...

core  

Astrocyte heterogeneity in brain metastases

Molecular Oncology, EarlyView.
Astrocytes emerge as pivotal regulators of metastatic colonization, survival, immune remodeling, and therapy response associated with an increasing heterogeneity that requires spatially and longitudinally resolved approaches to uncover regulatory programs and guide context‐specific therapies.
Carolina Hernández‐Oliver, Neibla Priego, Manuel Valiente   +2 more
wiley   +1 more source

From tumor‐centric to ecosystem‐based hypotheses in brain tumor research and care

Molecular Oncology, EarlyView.
Primary brain tumors, whether in adults or children, present a major challenge because of their dramatic prognosis and the ongoing lack of efficient therapeutic approaches. In recent years, a shift has occurred from tumor‐centric concepts to a more holistic view of these tumors as dynamic ecosystems.
Julie Gavard, Flavie Bénard, Eva Billat, Margaux Le Guyon, Victoria Maltret, Laura Merlet, Chloé Astrid Walter, Tony Avril, Eric Chevet   +8 more
wiley   +1 more source