Results 41 to 50 of about 196,920 (284)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

The corporate social performance of developing country multinationals [PDF]

, 2016
In this paper, we explore the Corporate Social Performance (CSP) of Developing Country Multinationals (DMNCs). We argue that in competing internationally, DMNCs often face both reputation and legitimacy deficits, which they address by improving their ...
Symeou, Pavlos, Williamson, Peter, Zyglidopoulos, Stylianos   +2 more
core   +1 more source

Differential cardiovascular and respiratory responses to central administration of selective opioid agonists in conscious rabbits: correlation with receptor distribution [PDF]

British Journal of Pharmacology, 1989
The effects of intracerebroventricular (i.c.v.) and intracisternal (i.c.) administration of a range of doses (0.01, 0.1 and 1.0 nmol kg−1) of specific μ‐ δ‐ and κ‐opioid agonists on cardiovascular and respiratory function and on plasma catecholamines have been studied in conscious rabbits. The distribution of μ‐ δ‐ and κ‐opioid receptors was localized
C N, May, M R, Dashwood, C J, Whitehead, C J, Mathias   +3 more
openaire   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Problems of ensuring women’s reproductive rights by criminal law means

Юридический вестник Самарского университета
From the standpoint of the constitutional law of Russia, the main international documents in the field of human rights and freedoms, a woman’s reproductive right is an important component of personal human rights and freedoms.
T. N. Nurkayeva
doaj   +1 more source

Administrative support staff in schools : ways forward [PDF]

, 2002
The aims of the research were to establish: • the impact of administrative support in school; • how teachers employ any time released by the presence of extra administrative support; • how the effective use of administrative support, including teacher
Bemrose, Rachael, Greene, Katy, Lee, Barbara, Springall, Ellen   +3 more
core  

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Joint Data Responsibility in Global Digital Trade: A Meso-Level Comparative Analysis of the European Union, the United States, and China

SAGE Open
Digital trade exposes increasing tensions between cross-border data flows, personal data protection, and national security. Existing scholarship has largely addressed these issues either at the macro level, through debates on data sovereignty, or at the ...
Yifan Guo
doaj   +1 more source

Encouraging Organizations to Develop and Take Measures to Prevent Corruption

Теоретическая и прикладная юриспруденция
Introduction. The article examines a number of problems of law enforcement of Article 13.3 of the Federal Law of December 25, 2008 No. 273-FZ “On Combating Corruption”, which establishes a general obligation of any organizations to develop and take ...
V. N. Churkin
doaj   +1 more source