Results 31 to 40 of about 10,005 (276)

Differential roles of GABAB1 subunit isoforms on locomotor responses to acute and repeated administration of cocaine

Behavioural Brain Research, 2016
GABAB receptors are crucial modulators of the behavioural effects of drug abuse, and agonists and positive allosteric modulators show promise as pharmacological strategies for anti-addiction therapeutics. GABAB receptors are functional heterodimers of GABAB1 and GABAB2 subunits.
Laura H. Jacobson, Fabian F. Sweeney, Klemens Kaupmann, Olivia F. O’Leary, Martin Gassmann, Bernhard Bettler, John F. Cryan   +6 more
openaire   +5 more sources

Differential Symptom Reporting by Mode of Administration of the Assessment [PDF]

Medical Care, 2009
Automated voice response (AVR) systems have been used to collect patient-reported outcome data. Mode of administration of the assessment may affect patient reporting.To evaluate if there is a differential reporting of symptoms by the mode of assessment: AVR versus a live telephone interview among cancer patients with solid tumors undergoing ...
Alla, Sikorskii, Charles W, Given, Barbara, Given, Sangchoon, Jeon, Mei, You   +4 more
openaire   +2 more sources

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

A study of subsidiaries views of information systems strategic planning in multinational organisations [PDF]

, 2007
This research examines information systems strategic planning (ISSP) in multinationals from the perspective of the subsidiaries. The research was carried out through interviews with the IT and business managers in subsidiaries of nine large American ...
Mohdzaher, Mohdzain, Ward, John
core   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Disputed issues of invalidity of an order (order) on bringing an employee to disciplinary responsibility

, 2021
In this article, the scientific community is invited to discuss the concept of invalidity of an order to bring an employee to disciplinary responsibility, the types of invalid orders, depending on the violations of the law and the rights of employees ...
Drachuk, Mariya A.
core  

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Problems of legal regulation of disciplinary liability of state civil servants: from principles to the system of penalties

Russian Studies in Law and Politics
Background. The article discusses the problems of implementing disciplinary responsibility of civil servants (hereinafter referred to as civil servants).
Anton G. Monetov
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Differential response of Iberian and lean pig crossbreeds to dietary linoleic acid administration

Spanish Journal of Agricultural Research, 2014
We aimed to determine whether the response of linoleic acid (C18:2 n-6) tissue concentration to dietary C18:2 n-6 administration, in the finishing period, is done in a different way in Iberian pig compared with a lean genotype. Therefore, 48 pigs, 24 of a lean genotype (Large White × Great York) and 24 of a fat genotype (Iberian × Duroc) were offered ...
Isabel, Beatriz, Cordero, Gustavo, Olivares, Alvaro, Daza, Argimiro, Lopez-Bote, Clemente J.   +4 more
openaire   +5 more sources