Results 11 to 20 of about 9,718 (234)

Differential Response to Sorafenib Administration for Advanced Hepatocellular Carcinoma

Biomedicines, 2022
Sorafenib has been used to treat advanced hepatocellular carcinoma (aHCC). However, there is no evidence for a response of different target lesions to sorafenib administration. Therefore, we aimed to evaluate the effect of sorafenib on various aHCC target lesions.
Song-Fong Huang, Sio-Wai Chong, Chun-Wei Huang, Heng-Yuan Hsu, Kuang-Tse Pan, Chien-Fu Hung, Tsung-Han Wu, Chao-Wei Lee, Chia-Hsun Hsieh, Ching-Ting Wang, Pei-Mei Chai, Ming-Chin Yu   +11 more
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Attenuation of Response to Repeated Drug Administration: A Proposal for Differentiating Tachyphylaxis and Tolerance [PDF]

The Journal of Pharmacology and Experimental Therapeutics, 2022
Attenuation of drug response with repeated administration is referred to as tachyphylaxis or tolerance, though the distinction between these two is obscured through both their usage in the literature and imprecise definitions in common pharmacology texts.
openaire   +2 more sources

Experimental Cardiac Fibrosis: Differential Time Course of Responses to Mineralocorticoid-Salt Administration [PDF]

Endocrinology, 2001
The rapid (1-4 h) responses of epithelial target tissues to mineralocorticoids contrast with the days/weeks apparently required for responses in the cardiovascular system. The present study explores the time course and pattern of early events leading to cardiac fibrosis in the mineralocorticoid-salt rat model.
G, Fujisawa, R, Dilley, M J, Fullerton, J W, Funder   +3 more
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Differentially methylated CpGs in response to growth hormone administration in children with idiopathic short stature

Clinical Epigenetics, 2022
Abstract Background Recombinant human growth hormone (rhGH) has shown a great growth-promoting potential in children with idiopathic short stature (ISS). However, the response to rhGH differs across individuals, largely due to genetic and epigenetic heterogeneity.
Shao, Xiaojian, Le Stunff, Catherine, Cheung, Warren, Kwan, Tony, Lathrop, Mark, Pastinen, Tomi, Bougnères, Pierre   +6 more
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Differential peptidomics assessment of strain and age differences in mice in response to acute cocaine administration [PDF]

Journal of Neurochemistry, 2015
AbstractNeurochemical differences in the hypothalamic‐pituitary axis between individuals and between ages may contribute to differential susceptibility to cocaine abuse. This study measured peptide levels in the pituitary gland (Pit) and lateral hypothalamus (LH) in adolescent (age 30 days) and adult (age 65 days) mice from four standard inbred strains,
Elena V, Romanova, Stanislav S, Rubakhin, John R, Ossyra, Jonathan A, Zombeck, Michael R, Nosek, Jonathan V, Sweedler, Justin S, Rhodes   +6 more
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Differential Effects of Age and Sex on the Postnatal Responsiveness of Brown Adipose Tissue to Prolactin Administration in Rats [PDF]

Experimental Physiology, 2003
Previous studies have shown that prolactin administration to pregnant rats results in offspring with enhanced abundance of the brown adipose tissue‐specific uncoupling protein (UCP) 1. The present study therefore aimed to determine whether a similar effect was observed after birth and if the sex of the animal further influenced the responsiveness of ...
Sarah, Pearce, Carlos, Dieguez, Oreste, Gualillo, Michael E, Symonds, Terence, Stephenson   +4 more
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Some Issues on Reforming the Legislation on Administrative Offences

Сибирское юридическое обозрение, 2020
Some problems of modern administrative-tort law are considered. Attention is focused on a number of key problems of the current legislation on administrative offenses and on some specific proposals for its amendment.
S. I. Koryts, I. B. Bokova
doaj  

Differential early response of monocyte/macrophage subsets to intra-operative corticosteroid administration in lung transplantation

Frontiers in Immunology, 2023
IntroductionLung transplantation often results in primary and/or chronic dysfunctions that are related to early perioperative innate allo-responses where myeloid subsets play a major role. Corticosteroids are administered upon surgery as a standard-of-care but their action on the different myeloid cell subsets in that context is not known.MethodsTo ...
Matthieu Glorion, Matthieu Glorion, Florentina Pascale, Florentina Pascale, Maxime Huriet, Jérôme Estephan, Carla Gouin, Céline Urien, Mickael Bourge, Giorgia Egidy, Christophe Richard, Valérie Gelin, Julien De Wolf, Morgan Le Guen, Antoine Magnan, Antoine Roux, Philippe Devillier, Philippe Devillier, Isabelle Schwartz-Cornil, Edouard Sage, Edouard Sage   +20 more
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Catalyzing marketing innovation and competitive advantage in the healthcare industry: the value of thinking like an outsider

BMC Health Services Research, 2018
Background Marketing arguably is the most critical administrative responsibility associated with the pursuit and realization of growth and prosperity, making prowess in the discipline essential for any healthcare institution, especially given the ...
James K. Elrod, John L. Fortenberry
doaj   +1 more source

Administrative Responsibility in the Field of Road Safety: Current Trends and Prospects

Сибирское юридическое обозрение, 2020
The article discusses the prospects and current trends of administrative responsibility in the field of road safety. The priorities of the state policy in the field of road safety are defined in the Strategy of road safety in the Russian Federation for ...
V. I. Maiorov, O. I. Beketov
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