Results 51 to 60 of about 2,527,767 (256)

Clinical and radiographic features of sarcoidosis in menopausal women: The impact on therapeutic approach and prognosis [PDF]

Vojnosanitetski Pregled, 2010
Background/Aim. Sarcoidosis is a multisystemic granulomatous disease of unknown etiology. The aim of the study was to determine are there significant differences in clinical manifestations, radiographic and lung function findings and therapeutic approach
Milošković Vladana R., Pešut Dragica P.   +1 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Pulmonary diffusing capacity for carbon monoxide and nitric oxide after COVID‐19: A prospective cohort study (the SECURe study)

Experimental Physiology
Many patients exhibit persistently reduced pulmonary diffusing capacity after coronavirus disease 2019 (COVID‐19). In this study, dual test gas diffusing capacity for carbon monoxide and nitric oxide (DL,CO,NO) metrics and their relationship to disease ...
Anna Agnes Lytzen, Thora Wesenberg Helt, Jan Christensen, Thomas Kromann Lund, Anna Kalhauge, Frederikke Falkencrone Rönsholt, Daria Podlekavera, Elisabeth Arndal, Anne‐Mette Lebech, Birgitte Hanel, Terese L. Katzenstein, Ronan M. G. Berg, Jann Mortensen   +12 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Impact of a 12‐week high‐intensity interval training intervention on cardiac structure and function after COVID‐19 at 12‐month follow‐up

Experimental Physiology
In patients previously hospitalised for COVID‐19, a 12‐week high‐intensity interval training (HIIT) intervention has previously been shown to increase left ventricular mass (LVM) immediately after the intervention.
Iben Elmerdahl Rasmussen, Mathilde Løk, Cody Garett Durrer, Anna Agnes Lytzen, Frederik Foged, Vera Graungaard Schelde, Josephine Bjørn Budde, Rasmus Syberg Rasmussen, Emma Fredskild Høvighoff, Villads Rasmussen, Mark Lyngbæk, Simon Jønck, Rikke Krogh‐Madsen, Birgitte Lindegaard, Peter Godsk Jørgensen, Lars Køber, Niels Vejlstrup, Bente Klarlund Pedersen, Mathias Ried‐Larsen, Morten Asp Vonsild Lund, Ronan M. G. Berg, Regitse Højgaard Christensen   +21 more
doaj   +1 more source

Value of lung diffusing capacity for nitric oxide in systemic sclerosis

Physiological Reports, 2019
A decreased lung diffusing capacity for carbon monoxide (DLCO) in systemic sclerosis (SSc) is considered to reflect losses of alveolar membrane diffusive conductance for CO (DMCO), due to interstitial lung disease, and/or pulmonary capillary blood volume
Giovanni Barisione, Alessandro Garlaschi, Mariaelena Occhipinti, Michele Baroffio, Massimo Pistolesi, Vito Brusasco   +5 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

The need for race-specific reference equations for pulmonary diffusing capacity for nitric oxide

BMC Pulmonary Medicine, 2021
Background Few reference equations exist for healthy adults of various races for pulmonary diffusing capacity for nitric oxide (DLNO). The purpose of this study was to collect pilot data to demonstrate that race-specific reference equations are needed ...
Gerald Stanley Zavorsky, Ahmad Saleh Almamary, Mobarak Khalid Alqahtani, Shi Huh Samuel Shan, Douglas Shawn Gardenhire   +4 more
doaj   +1 more source

Simultaneous measurement of lung diffusing capacity and pulmonary hemodynamics reveals exertional alveolar-capillary dysfunction in heart failure with preserved ejection fraction

, 2021
BACKGROUND: Hemodynamic perturbations in heart failure with preserved ejection fraction (HFpEF) may alter the distribution of blood in the lungs, impair gas transfer from the alveoli into the pulmonary capillaries, and reduce lung diffusing capacity.
Borlaug, BA, Johnson, BD, Fermoyle, CC, Stewart, GM   +3 more
core   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source