Results 41 to 50 of about 2,527,767 (256)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

open access: yesFEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Interplay between the morphometry of the lungs and the mode of locomotion in birds and mammals

open access: yesBiological Research, 2007
We studied the lung diffusion parameters of two species of birds and two species of mammals to explore how structural and functional features may be paralleled by differences in life style or phylogenetic origin.
DANIELA FIGUEROA   +4 more
doaj  

The Reliability of a Novel Structured Testing Device for Single-breath Lung Carbon Monoxide Uptake: A Randomized Comparison Crossover Study

open access: yesBMC Pulmonary Medicine
Background With the development and market launch of several new domestic lung diffusing capacity testing instruments, the clinical reliability of the MeHow MeAir 9000 spirometer, featuring a novel turning valve structure, needs to be validated ...
Shihua Yao   +13 more
doaj   +1 more source

Postural variation of pulmonary diffusing capacity as a marker of lung microangiopathy in Indian patients with type 2 diabetes mellitus

open access: yesIndian Journal of Endocrinology and Metabolism, 2016
Introduction: Diabetes mellitus (DM) is characterized by the presence of chronic hyperglycemia and formation of advanced glycation end products (AGEs). Interaction between AGE and its receptor leads to endothelial damage and microangiopathy.
Avinash Kumar   +4 more
doaj   +1 more source

Diffusing capacity predicts operative mortality but not long-term survival after resection for lung cancer [PDF]

open access: yes, 1999
Objectives: We sought to determine whether diffusing capacity influences operative mortality and long-term survival after resection for lung cancer. Methods: We retrospectively reviewed the case histories of patients who underwent major resection for ...
Olak, Jemi, Wang, Jun, Ferguson, Mark K.
core   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

open access: yesFEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace   +6 more
wiley   +1 more source

Is Lymphopenia Detected in Sarcoidosis Associated with the Disease Activity?

open access: yesSouthern Clinics of Istanbul Eurasia, 2019
INTRODUCTION[|]The association of lymphopenia detected in patients with sarcoidosis with disease activity was investigated in the present study.[¤]METHODS[|]Patients who were diagnosed as having sarcoidosis and healthy volunteers/individuals with no ...
Coşkun Doğan   +7 more
doaj   +1 more source

Regional diffusing capacity in normal lungs during a slow exhalation

open access: yes, 1982
From an analysis of carbon monoxide uptake and xenon-133 distribution after two bolus inhalations of these gases, we calculated regional diffusing capacity in the upper and lower volume halves of the lungs during the middle 60% of an exhaled vital ...
N. R. MacIntyre, J. A. Nadel
core   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

open access: yesFEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar   +4 more
wiley   +1 more source

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