Results 101 to 110 of about 3,370,652 (304)

White Matter Microstructural Abnormalities in Neonatal Onset Genetic Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Recent evidence indicates that epilepsy is associated with abnormal white matter. If seizures alter white matter, then the impact upon network function, epileptogenesis, and cognition could be pronounced in neonates undergoing rapid developmental myelination. Neonates with epilepsy due to nonstructural genetic causes provide a unique
Amanda G. Sandoval Karamian, Tianjia Zhu, Hao Huang, Shavonne L. Massey, Mark P. Fitzgerald, Darshana Parikh, Arastoo Vossough, Ingo Helbig, Nicholas S. Abend   +8 more
wiley   +1 more source

Neurochemical Endpoints to Inform Early‐Stage Trials of Spinocerebellar Ataxia 2 and 3 in a Multisite Setting

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neurochemical levels measured by brain MR spectroscopy (MRS) have been proposed as endpoints for clinical trials in early‐stage spinocerebellar ataxia (SCA) trials. We tested their trial‐readiness by quantifying neurochemicals in three affected brain regions in early‐stage cohorts of SCA2 and SCA3, examining their reproducibility in ...
James M. Joers, Yaqiao Wei, Dinesh K. Deelchand, Adam Berrington, Young Woo Park, Guita Banan, Michal Povazan, Jens T. Rosenberg, André J. W. van der Kouwe, Tetsuo Ashizawa, Khalaf O. Bushara, Chiadi U. Onyike, Sub H. Subramony, Jeremy D. Schmahmann, Brian J. Soher, Peter B. Barker, Thomas H. Mareci, Eva‐Maria Ratai, Lynn E. Eberly, Gülin Öz   +19 more
wiley   +1 more source

Diffusion-Weighted Imaging of the Pituitary Gland [PDF]

American Journal of Neuroradiology, 2013
In this issue of the American Journal of Neuroradiology , you will find the article “Evaluation of Diffusivity in the Anterior Lobe of the Pituitary Gland: 3D Turbo Field Echo with Diffusion-Sensitized Driven-Equilibrium Preparation” by Hiwatashi et al.[1][1] I enjoyed reading this article ...
openaire   +2 more sources

T1 Over Squared Proton Density Ratio to Characterize Multiple Sclerosis Lesions

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Differentiating remyelinated from demyelinated lesions in MS remains challenging without histological confirmation. This study introduces the T1‐to‐PD2 ratio (TPR) imaging approach and evaluates its ability to characterize MS lesions alongside other quantitative MRI (qMRI) metrics. Methods Thirty individuals with MS (mean age: 47.5 ± 
Sarah J. Wright, Scotty G. McKay, Jean Ramos Bou, Fen Bao, Vivian B. Truong, Chenyang Li, Li Jiang, Anza B. Memon, E. Mark Haacke, Yulin Ge, Yongsheng Chen   +10 more
wiley   +1 more source

Diffusion-weighted imaging in the head and neck region: usefulness of apparent diffusion coefficient values for characterization of lesions [PDF]

, 2015
PURPOSEWe aimed to evaluate the role of apparent diffusion coefficient (ADC) values calculated from diffusion-weighted imaging for head and neck lesion characterization in daily routine, in comparison with histopathological results.METHODSNinety ...
Murat Damar, Ömer Yazgan, Zuhal Erdem, İsmail Şerifoğlu, Özlem Tokgöz, İbrahim İlker Oz   +5 more
core   +1 more source

Human Pegivirus Encephalitis With Brain Detection and Response to Sofosbuvir Ledipasvir

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Human pegivirus (HPgV‐1) has been associated with severe encephalomyelitis in immunocompromised patients. Its neurological spectrum remains poorly defined. We report a slowly progressive encephalitis in a person living with well‐controlled HIV, characterized by white matter abnormalities and inflammatory cerebrospinal fluid (CSF). HPgV RNA was
Antoine Moulignier, Françoise Heran, Francis Lallemand, Pierre Bourdillon   +3 more
wiley   +1 more source

Thalamo‐Lesional Connectivity Signatures of Bilateral Tonic–Clonic Seizures in Focal Cortical Dysplasia‐Related Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Focal cortical dysplasia (FCD) is the most common etiology of drug‐resistant epilepsy in children. Focal to bilateral tonic–clonic seizures (FBTCS) mark a high risk of drug‐resistant epilepsy and involve thalamocortical circuitry in their generation and propagation.
Hua Xie, Xiaotong Li, Venkata Sita Priyanka Illapani, Leigh N. Sepeta, Jason Schroeder, Chima O. Oluigbo, Madison M. Berl, William D. Gaillard, Nathan T. Cohen   +8 more
wiley   +1 more source

Diffusion-weighted magnetic resonance imaging detects significant prostate cancer with high probability [PDF]

, 2014
PURPOSE We prospectively assessed the diagnostic accuracy of diffusion-weighted magnetic resonance imaging for detecting significant prostate cancer. MATERIALS AND METHODS We performed a prospective study of 111 consecutive men with prostate and/
Bains, Lauren, Triantafyllou, Maria, Studer, Urs, Froehlich, Johannes M, Fleischmann, Achim, Thöny, Harriet C., Giannarini, Gianluca   +6 more
core   +1 more source

Characterizing Cutaneous α‐Synuclein Deposition and Seeding Activity in Parkinson's Disease Subtypes

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cutaneous phosphorylated α‐synuclein (p‐syn) and α‐synuclein seeding activity are promising biomarkers for Parkinson's disease (PD), but their clinical value remains uncertain due to disease heterogeneity. This study evaluates these two biomarkers in PD patients to inform phenotype‐specific diagnosis and disease severity assessment ...
Yuting Jin, Tianyuan Yang, Minglei Liu, Haiyang Luo, Jing Yuan, Ke Zhang, Xinsheng Han, Jing Yang, Yuming Xu   +8 more
wiley   +1 more source

EPITHET: Positive Result After Reanalysis Using Baseline Diffusion-Weighted Imaging/Perfusion-Weighted Imaging Co-Registration

, 2011
Background and Purpose-The Echoplanar Imaging Thrombolytic Evaluation Trial (EPITHET) was a prospective, randomized, double-blinded, placebo-controlled, phase II trial of alteplase between 3 and 6 hours after stroke onset.
Kimber, T., Nagakane, Yoshinari, Levi, Christopher R, Levi, CR, Parsons , Mark W, Bladin, Christopher F, Brekenfeld, Caspar, Fink, J, Schultz, David W, Tress, B. M., Kimber , Thomas E, De Silva , Deidre A, Thomas E. Kimber, Levi, C. R., Kimber, TE, Muir, KW, Levi, C., Fink , John, Butcher, K., Leonid Churilov, John Fink, Christensen , Soren, Patricia M. Desmond, EPITHET Investigators,, Churilov, Leonid, Ma, H, Butcher, K. S., Desmond, PM, Tress, BM, Kimber, Thomas E, Muir, K., Keith W. Muir, Peeters, A, Muir, Keith W, P. Alan Barber, Mark W. Parsons, Davis, Stephen M, Fink, John, Desmond, P., Butcher, Kenneth S, Christensen, S., Donnan Geoffrey, A, Davis, S. M., Nagakane, Y, Tress, B., Brian M. Tress, Bladin , Christopher F, Yoshinari Nagakane, Barber, P Alan, Donnan, G. A., Christopher F. Bladin, Kimber, T. E., Henry Ma, Desmond , Patricia M, Davis, SM, De Silva, D., Schultz, D., Desmond, Patricia M, Nagakane, Y., Bladin, CF, Parsons, MW, Brekenfeld, C, De Silva, DA, EPITHET Investigators, Bladin, C. F., Desmond, P. M., Peeters, A., Barber, P. A., Christensen, Soren, Davis, S., Levi , Christopher R, Deidre A. De Silva, Barber, Peter, Geoffrey A. Donnan, Barber , P Alan, Stephen M. Davis, Caspar Brekenfeld, Andre Peeters, Christensen, S, Schultz , David W, Kenneth S. Butcher, De Silva, D. A., Butcher , Kenneth S, Parsons, M., Churilov , Leonid, Nagakane , Yoshinari, Peeters, Andre, Parsons, M. W., Donnan, Geoffrey A, Fink, J., Christopher R. Levi, Butcher, KS, Donnan, G., Schultz, D. W., Parsons, Mark W, Muir , Keith W, Ma, H., Donnan, GA, Muir, K.W., Churilov, L, Soren Christensen, De Silva Deidre, A, Ma , Henry, Churilov, L., Tress, Brian M, Ma, Henry, Bladin, C., Barber, P., Brekenfeld , Caspar, Brekenfeld, C., David W. Schultz, Schultz, DW   +111 more
core   +1 more source