Results 91 to 100 of about 917,432 (268)

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Ontology Maintenance using Textual Analysis [PDF]

Journal of Systemics, Cybernetics and Informatics, 2003
Ontologies are continuously confronted to evolution problem. Due to the complexity of the changes to be made, a maintenance process, at least a semi-automatic one, is more and more necessary to facilitate this task and to ensure its reliability.
Yassine Gargouri, Bernard Lefebvre, Jean-Guy Meunier   +2 more
doaj  

Tempered Fractional Equations for Quantum Transport in Mesoscopic One-Dimensional Systems with Fractal Disorder

Fractal and Fractional, 2019
New aspects of electron transport in quantum wires with Lévy-type disorder are described. We study the weak scattering and the incoherent sequential tunneling in one-dimensional quantum systems characterized by a tempered Lévy stable ...
Renat T. Sibatov, HongGuang Sun
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Diffusion In Diffusion: Reclaiming Global Coherence in Semi-Autoregressive Diffusion

CoRR
One of the most compelling features of global discrete diffusion language models is their global bidirectional contextual capability. However, existing block-based diffusion studies tend to introduce autoregressive priors, which, while offering benefits, can cause models to lose this global coherence at the macro level.
Linrui Ma, Yufei Cui, Kai Han 0002, Yunhe Wang 0001   +3 more
openaire   +2 more sources

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source

Granulometric Analysis on Remote Sensing Images: Application to Mapping Retrospective Changes in the Sahelian Ligneous Cover

ISPRS International Journal of Geo-Information, 2016
This paper illustrates how the use of mathematical morphology can be a powerful tool for the mapping of ligneous cover in semi-arid lands. Ligneous cover plays a fundamental role in Sahel semi-arid regions since this resource is vital to the resilience ...
José Luis San Emeterio, Catherine Mering   +1 more
doaj   +1 more source

Efficient Diffusion Planning with Temporal Diffusion

Proceedings of the AAAI Conference on Artificial Intelligence
Diffusion planning is a promising method for learning high-performance policies from offline data. To avoid the impact of discrepancies between planning and reality on performance, previous works generate new plans at each time step. However, this incurs significant computational overhead and leads to lower decision frequencies, and frequent plan ...
Jiaming Guo, Rui Zhang 0040, Zerun Li, Yunkai Gao 0001, Shaohui Peng, Siming Lan, Xing Hu 0001, Zidong Du, Xishan Zhang, Ling Li 0001   +9 more
openaire   +2 more sources