Results 101 to 110 of about 399,973 (265)

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

ETIA: Enhancing Text2Image Surround View Scene Generation With Semantic Annotation via Diffusion for Autonomous Driving

IEEE Access
Generating high-fidelity surround view images from text prompts is a complex task that requires balancing contextual coherence with computational efficiency. The proposed work introduces a novel methodology that combines recurrent attention-based encoder-
Ramyashree, S. Raghavendra, S. K. Abhilash, Venu Madhav Nookala, P. V. Arun Kumar, P. Malashree   +5 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

SynAdult: Multimodal Synthetic Adult Dataset Generation via Diffusion Models and Neuromorphic Event Simulation for Critical Biometric Applications

IEEE Access
We propose SynAdult, a multimodal synthetic data generation framework designed to address the scarcity of diverse and privacy-compliant senior adult face datasets for biometric applications and facial analysis.
Muhammad Ali Farooq, Paul Kielty, Wang Yao, Peter Corcoran   +3 more
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Using generative AI to transform peptide hits into small molecule leads

Beilstein Journal of Organic Chemistry
There is a wealth of structural data on peptides that bind potential drug targets, serving as rich inspiration for designing small molecule inhibitors which can recapitulate key binding interactions while improving pharmacokinetic properties.
Joshua Mills, Yu Heng Lau
doaj   +1 more source

DADSR: Degradation-Aware Diffusion Super-Resolution Model for Object-Level SAR Image

IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing
Synthetic aperture radar (SAR) plays a vital role in remote sensing applications but suffers from coupled degradation problems, including resolution deterioration, speckle noise, and defocusing effects, primarily caused by system limitations, imaging ...
Zilong Chen, Caiguang Zhang, Chengyu Wan, Siqian Zhang, Boli Xiong   +4 more
doaj   +1 more source