Results 151 to 160 of about 8,073,665 (296)

Structural and biochemical insights into the thermostable esterase Ta0887 from Thermoplasma acidophilum

FEBS Open Bio, EarlyView.
In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey, Miriam Livier Llamas‐García, Gabriela M. Montero‐Morán, Leticia Santos, Samuel Lara‐González   +4 more
wiley   +1 more source

Conditional Diffusion-Flow models for generating 3D cosmic density fields: applications to f(R) cosmologies

Machine Learning: Science and Technology
Next-generation galaxy surveys promise unprecedented precision in testing gravity at cosmological scales. However, realising this potential requires accurately modelling the non-linear cosmic web.
Julieth K Riveros, Paola A Saavedra, Héctor J Hortúa, Jorge Enrique García-Farieta, Ivan Olier   +4 more
doaj   +1 more source

AWARE: Augmentation for Weather-Adverse Robustness Evaluation—Benchmarking Strategies for Improved Semantic Segmentation Under Challenging Outdoor Conditions

IEEE Access
Among recent advances in AI, the progress in synthetic image generation stands out as particularly notable. State-of-the-art models can synthesize controllable photorealistic images that are nearly indistinguishable from real photographs.
Christoph Gerhardt, Muhammad Momin Salman, Wolfgang Broll   +2 more
doaj   +1 more source

Threonine 348 regulates the subcellular localization of PTEN

FEBS Open Bio, EarlyView.
Thr348 in the C2 domain is a key contributor to PTEN subcellular localization. The PTEN350 fragment and PTENA4 accumulated in the nucleus, whereas PTENK13R,A4 predominantly localized to the plasma membrane. In contrast, substitution of Thr348 with Asp (T348D) disrupted these characteristic localization patterns, resulting in predominant cytoplasmic ...
Takashi Kato, Suzu Tanaka, Miyu Ohashi
wiley   +1 more source

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source

MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation

FEBS Open Bio, EarlyView.
MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima, Kotone Watanabe, Grigorii Sultanakhmetov, Aoi Fukuchi, Keiya Ito, Sawako Shimizu, Taro Saito, Akiko Asada, Kanae Ando   +8 more
wiley   +1 more source

A fractal based model of diffusion MRI in cortical grey matter [PDF]

, 2009
Diffusion Weighted Magnetic Resonance (DWMR) Imaging is an important tool in diagnostic neuroimaging, but the biophysical basis of the DWMR signal from biological tissue is not entirely understood. Testable, theoretical models relating the DWMR signal to
Hansen, Brian, Østergaard, Leif, Vestergaard-Poulsen, Peter   +2 more
core  

Recent insights into the molecular mechanism of ubiquinol oxidation by cytochrome bc1

FEBS Open Bio, EarlyView.
The review reflects on the mechanism of the catalytic reaction in cytochrome bc1: the electron bifurcation that involves the separation of two electrons derived from the quinol oxidation to opposite sides of the enzyme across the membrane. This review summarizes the long‐standing effort to understand the mechanism of quinol oxidation catalyzed by ...
Anna Wójcik‐Augustyn, Artur Osyczka, Marcin Sarewicz   +2 more
wiley   +1 more source

Using fluorescence fluctuation spectroscopy to quantify molecular dynamics within cells

FEBS Open Bio, EarlyView.
Microscopy techniques like fluorescence correlation spectroscopy (FCS) and number and brightness analysis (N&B) allow to quantify concentrations, diffusion rates, and oligomerization of fluorescently labeled molecules in the living cell. In this protocol the principles of how to set up these types of experiments are described including calibration ...
Mark A. Hink
wiley   +1 more source

Modeling brain extracellular space from diffusion data [PDF]

, 2007
The extracellular space (ECS) of the brain is a thin region surrounding each cell that is filled with a medium resembling cerebrospinal fluid and an unknown amount of extracellular matrix. The ECS is difficult to study but diffusion measurements based on
Nicholson, Charles
core