Results 71 to 80 of about 1,419,860 (293)

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

On the transformation of diffusion processes into the Wiener process

Journal of Mathematical Analysis and Applications, 1976
AbstractNecessary and sufficient conditions for transforming into the Wiener process a one-dimensional diffusion process descibed by a Kolmogorov or by a Langevin equation are provided, and the transformation is determined. The relationship of these conditions with the criterion due to Cherkasov is exploited. A few examples are discussed.
openaire   +3 more sources

Black hole motion in Euclidean space as a diffusion process

, 2012
A diffusion equation for a black hole is derived from the Bunster-Carlip equations. Its solution has the standard form of a Gaussian distribution. The second moment of the distribution determines the quantum of black hole area.
A. Barvinsky, K. Ropotenko
core   +2 more sources

Elucidating prognostic significance of purine metabolism in colorectal cancer through integrating data from transcriptomic, immunohistochemical, and single‐cell RNA sequencing analysis

Molecular Oncology, EarlyView.
Low expression of five purine metabolism‐related genes (ADSL, APRT, ADCY3, NME3, NME6) was correlated with poor survival in colorectal cancer. Immunohistochemistry analysis showed that low NME3 (early stage) and low ADSL/NME6 (late stage) levels were associated with high risk.
Sungyeon Kim, Myunghee Kang, Soyeon Jeong, Jisup Kim, Kyoung Oh Kim, Won‐Suk Lee, Jeong‐Heum Baek, Jung Ho Kim, Seungyoon Nam   +8 more
wiley   +1 more source

Salient Region Detection Using Diffusion Process with Nonlocal Connections

Applied Sciences, 2018
Diffusion-based salient region detection methods have gained great popularity. In most diffusion-based methods, the saliency values are ranked on 2-layer neighborhood graph by connecting each node to its neighboring nodes and the nodes sharing common ...
Huiyuan Luo, Guangliang Han, Peixun Liu, Yanfeng Wu   +3 more
doaj   +1 more source

Retarding Sub- and Accelerating Super-Diffusion Governed by Distributed Order Fractional Diffusion Equations

, 2002
We propose diffusion-like equations with time and space fractional derivatives of the distributed order for the kinetic description of anomalous diffusion and relaxation phenomena, whose diffusion exponent varies with time and which, correspondingly, can
A. Ayache, A. Compte, A. V. Chechkin, A. V. Chechkin, B. J. West, C. Fox, E. Barkai, E. Barkai, E. Lutz, E. W. Montroll, F. Igloi, F. Mainardi, F. Mainardi, G. Zumofen, I. M. Sokolov, I. M. Sokolov, J. Dräger, J. Klafter, J.-P. Bouchaud, K. Diethelm, M. Caputo, M. Caputo, R. Gorenflo, R. Hilfer, R. L. Bagley, R. L. Bagley, R. Metzler, R. Metzler, T. Prosen, Y. G. Sinai   +29 more
core   +1 more source

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

Molecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau, Hayley S. Smith, Begüm Alural, Claire E. Martin, Laura A. New, Manali Tilak, Sara L. Banerjee, Hannah N. Robeson, Nicolas Bisson, Anne‐Claude Gingras, Jasmin Lalonde, Nina Jones   +11 more
wiley   +1 more source

Ubiquitination of transcription factors in cancer: unveiling therapeutic potential

Molecular Oncology, EarlyView.
In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
wiley   +1 more source

Creating the First Autonomous Systems of Internet in Siberia as a Spatial Diffusion of Innovations

Prostranstvennaâ Èkonomika
The spread of innovations affects the socio-economic development of regions, but the specifics of such a spread are not always clear. Contagious or hierarchical spatial diffusion is usually studied.
Viktor Ivanovich Blanutsa
doaj   +1 more source

Voltamperometry of a Kinetically Irreversible Electrochemical Process on a Rough Electrode

Конденсированные среды и межфазные границы, 2020
We investigated the role of the effect of morphological inhomogeneity of the electrode surface in the voltammetric response of the irreversible electrochemical process in the mixed-kinetic mode.
Evgeniya V. Bedova, Darya I. Kolganova, Oleg A. Kozaderov   +2 more
doaj   +1 more source