Results 91 to 100 of about 697,935 (242)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Efecto de la adición de cepas probióticas sobre metabolitos sanguíneos en cerdos en crecimiento

Biotecnología en el Sector Agropecuario y Agroindustrial, 2015
El destete es la fase más crítica del cerdo, produciendo trastornos intestinales y diarreas. Para prevenirlo, se han utilizado antibióticos promotores de crecimiento (APC), generando residuos medicamentosos en el producto final.
Santiago Londoño Pérez, Jaime Parra Suescún   +1 more
doaj   +2 more sources

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Digestión y bioaccesibilidad in vitro de fosfatidilhidroxitirosol

, 2014
Resumen del póster presentado en las I Jornadas Científicas CIAL Forum 2014, celebrado en Madrid el 5 de junio de 2014.El hidroxitirosol (HT) es un compuesto fenólico señalado como uno de los responsables de los efectos beneficiosos sobre la salud del ...
Morán-Valero, María I., Reglero, Guillermo, Torres, Carlos F., Martín, Diana, Casado, Víctor   +4 more
core  

Digestión anaerobia de residuos de biomasa para la producción de biogás. Fundamentos [PDF]

, 2016
En este artículo vamos a presentar los fundamentos de la digestión anaerobia, particularizando en la mezcla de diversas materias primas o codigestión de residuos ganaderos, agrícolas y agroindustriales. Este proceso genera dos subproductos que pueden ser
Palau C.V.
core  

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

FEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu, Lanlan Li, Wenjuan Jia, Hanzhong Feng, Xiaoquan Yu, Youli Zhao, Fengzhi Yuan, Hui Ding, Junqiang Tian, Yong‐Xing He, Zhiping Wang   +10 more
wiley   +1 more source

Aprovechamiento energético de los residuos hortofrutícolas de la plaza de mercado de Sincelejo mediante digestión anaerobia

Fruit and vegetable residues (HR) represent sustainable and renewable resources that could be valorized in different applications providing alternatives thanks to the availability, high content of polysaccharides, micronutrients and moisture.
Moreno Rocha, Christian Manuel, Salgado Angulo, Kleyder José, Núñez Alvarez, José Ricardo   +2 more
core   +1 more source

Digestión anaerobia de subproductos de la industria cárnica [PDF]

, 2010
En los últimos años, el GIRO ha trabajado en diferentes líneas de investigación relativas a la digestión anaerobia de subproductos animales (SPA) de la industria cárnica.
Fernández García, Belén, Flotats Ripoll, Xavier, Rodríguez-Abalde, Ángela, Palatsi Civit, Jordi   +3 more
core   +1 more source