Results 181 to 190 of about 1,193,866 (323)

Requirement of Digestible Sulfur Amino Acids in Laying Hens Fed Sorghum- and Soybean Meal-Based Diets

Two experiments were done to evaluate the effect of increasing levels of dietary digestible methionine (Met) and Met:cysteine (Met:Cys) ratio on the productivity of Hy-Line W-36 laying hens fed sorghum- and soybean meal-based diets. In Exp.
RS Gomez, ML Angeles
core   +1 more source

Androgen Receptor‐Induced Lactoferrin Accelerates Prostate Tumorigenesis Through Modulating Ferroptosis

Advanced Science, EarlyView.
This study demonstrates that transcription factor androgen receptor (AR) directly binds the LF promoter, driving lactoferrin overexpression to promote ferritin (FTH1/FTL) upregulation and inhibit p53‐ALOX12‐mediated ferroptosis in prostate cancer. Lactoferrin could be a new potential therapeutic target in prostate cancer.
Can Liu, Qiu Peng, Xiaoyue Zhang, Zhengshuo Li, Yangge Wu, Yuqing Wen, Run Zheng, Shuanglong Wu, Chenfei Zhou, Zhengyu Hu, Lanjun Shu, Xinyi Ma, Qiuyang Li, Ya Ma, Chunlin Ou, Ming Zhao, Songqing Fan, Lingyu Wei, Jian Ma   +18 more
wiley   +1 more source

Modeling improvements in digestible amino acids by a consensus bacterial 6-phytase variant in grower pigs. [PDF]

J Anim Sci
Velayudhan D, Dersjant-Li Y, Lizardo R, Kumar A, Stein HH, Espinosa CD, Cantarelli V, Hardy R, Vinyeta E, Marchal L.   +9 more
europepmc   +1 more source

Optimisation of distillery co-products for poultry feed

, 2012
EU legislation has led to an almost ten-fold increase in bioethanol production between 2003 and 2011. The current distillery co-product, distiller’s dried grains with solubles (DDGS), is fed primarily to cattle due to the high fibre content but ...
Scholey, DV
core  

Molecular Glue cc‐885 Inhibits VHL‐Deficient Clear Cell Renal Cell Carcinoma via ETS1 Degradation

Advanced Science, EarlyView.
VHL‐deficient kidney cancer lacks effective treatments. This study reveals that the molecular glue degrader cc‐885 hijacks the cellular recycling system to selectively destroy the oncogenic protein ETS1, effectively killing VHL‐mutant tumors. Combining CC‐885 with the approved drug belzutifan achieves powerful synergy, offering a promising new ...
Taowei Yang, Qihao Li, Kun Ye, Kezhi Liu, Mi Zhou, Minyu Chen, Lican Liao, Kangbo Huang, Zhu Wang, Qiong Deng, Jieyan Wang, Meiyu Jin, Xu Chen, Hui Liang, Jiaxing Zhang, Junhang Luo   +15 more
wiley   +1 more source

Quantitative Mass Spectrometry‐Based Biodistribution of Monoclonal Antibodies: An Alternative to Radio‐Biodistribution

Advanced Science, EarlyView.
Monoclonal antibodies are powerful anticancer therapeutics targeting tumor‐associated antigens. Mass spectrometry enables precise and accurate quantification of mAbs in tumor plasma and healthy organs. Unlike ligand binding assay and radioactivity, mass spectrometry does not suffer from matrix effects and labelling artefacts while facilitating method ...
Domenico Ravazza, Sheila Dakhel Plaza, Samuele Cazzamalli, Andrea Ciamarone, Andrea Galbiati, Riccardo Stucchi, Frederik Peissert, Emanuele Puca, Dario Neri, Ettore Gilardoni   +9 more
wiley   +1 more source

Application of a minerals, digestible amino acids and energy matrix to a broiler diet supplemented with a bacterial 6-phytase maintained growth performance and reduced feed costs compared to a minerals matrix alone. [PDF]

Poult Sci
Bello A, Haldar S, Ghane AE, de Kreij A, Hardy R, Dersjant-Li Y.   +5 more
europepmc   +1 more source

PSMA8‐Containing 20S Proteasome Regulates Spermiogenesis and Male Fertility

Advanced Science, EarlyView.
PSMA8 assembles s20S proteasome that degrades specific substrates in elongating spermatids. Degradation of s20S‐substrates activates translation of FXR1‐target mRNAs, which are essential for mitochondrial sheath formation and sperm morphogenesis.
Huiwen Cao, Qianting Zhang, Wei Xu, Anxuan Fang, Haomang Xu, Cheng Qiu, Lugeng He, Chao Yu   +7 more
wiley   +1 more source

Effects of dietary digestible amino acids and a novel exogenous sfericase protease on growth performance of broilers. [PDF]

Heliyon
Stefanello C, Dalmoro YK, P Rosa D, Teixeira L, B Sorbara JO, J Cowieson A, Faruk MU.   +6 more
europepmc   +1 more source