Results 41 to 50 of about 2,631,756 (296)

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

CCN1 promotes APRIL/BAFF signaling in esophageal squamous cell carcinoma but attenuates it in esophageal adenocarcinoma

Scientific Reports
CCN1 is a matricellular protein highly expressed in esophageal squamous cell carcinoma (ESCC) but hardly detectable in esophageal adenocarcinoma (EAC). Expression of CCN1 in EAC cells leads to TRAIL-mediated apoptosis.
Lingling Xing, Zhenyu Jiang, Ruize Xu, Tong Dang, Jinbao Wu, Jianyuan Chai, Xianmei Meng   +6 more
doaj   +1 more source

Gut microbiome and metabolome signatures in liver cirrhosis-related complications [PDF]

Clinical and Molecular Hepatology
Background/Aims Shifts in the gut microbiota and metabolites are interrelated with liver cirrhosis progression and complications. However, causal relationships have not been evaluated comprehensively.
Satya Priya Sharma, Haripriya Gupta, Goo-Hyun Kwon, Sang Yoon Lee, Seol Hee Song, Jeoung Su Kim, Jeong Ha Park, Min Ju Kim, Dong-Hoon Yang, Hyunjoon Park, Sung-Min Won, Jin-Ju Jeong, Ki-Kwang Oh, Jung A Eom, Kyeong Jin Lee, Sang Jun Yoon, Young Lim Ham, Gwang Ho Baik, Dong Joon Kim, Ki Tae Suk   +19 more
doaj   +1 more source

Treatment of achalasia with peroral endoscopic myotomy in situs inversus totalis

DEN Open, 2022
Peroral endoscopic myotomy (POEM) has become established as a safe, effective, and versatile minimally invasive endoscopic treatment for achalasia and other esophageal motility disorders. Situs inversus totalis is a rare congenital disorder characterized
Mary Raina Angeli Fujiyoshi, Yuto Shimamura, Yusuke Fujiyoshi, Kei Ushikubo, Yuki Shibata, Yohei Nishikawa, Masashi Ono, Haruo Ikeda, Manabu Onimaru, Haruhiro Inoue   +9 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Influence du sevrage précoce sur la sensibilité des lapereaux à une infection expérimentale par une souche d'Escherichia coli entéropathogène O103:H2 [PDF]

, 2005
La période du péri-sevrage en production cunicole est particulièrement difficile à gérer pour les éleveurs qui doivent concilier les impératifs de gestion et une sensibilité accrue des lapereaux aux infections notamment digestives.
Coudert, Cécile
core  

Nutrition During Digestive System Diseases

, 2011
Bakalářská práce je zaměřena na výživu při onemocnění trávicího traktu. Definuje zánětlivá střevní onemocnění tj. Crohnovu chorobu a ulcerózní kolitidu, průjem a zácpu. Popisuje příznaky a průběh jednotlivých onemocnění.
Hladil, Zdeněk
core   +2 more sources

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Deficiency of SIAH1 promotes the formation of filopodia by increasing the accumulation of FASN in liver cancer

Cell Death and Disease
It has been shown that the formation of filopodia is a key step in tumor cell metastasis, but there is limited research regarding its mechanism. In this study, we demonstrated that fatty acid synthase (FASN) promoted filopodia formation in liver cancer ...
Zhiyi Liu, Qinghe Hu, Kuan Cao, Jun Sun, Licheng Cui, Mengxuan Ji, Wengang Shan, Weichao Yang, Guowei Zhang, Zilu Tian, Hengliang Shi, Bin Zhang, Renhao Wang   +12 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source